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Your search keyword '"Haiyu Zhao"' showing total 4 results
Start Over Author "Haiyu Zhao" Journal animal biotechnology
4 results on '"Haiyu Zhao"'

1. Exploring the distribution of polymorphism across diverse breeds Worldwide in the bovine NR5A2 gene and its correlation with number of mature follicles and corpus albicans

Author

Enhui Jiang, Xuanbo Chen, Taotao Yan, Yi Bi, Juanshan Zheng, Haiyu Zhao, Yongsheng Wang, Xiangchen Li, and Xianyong Lan

Subjects
Cow, NR5A2 gene, deletion, ovary, reproduction, Biotechnology, TP248.13-248.65
Abstract

The Nuclear receptor subfamily 5 group A member 2 (NR5A2) gene plays a pivotal role in ovarian development, ovulation, and reproductive traits. There is a lack of studies on its impact on ovarian traits and reproductive traits in cattle. This study aimed to explore NR5A2 gene polymorphisms associations with reproductive traits and investigate the distribution of NR5A2 gene polymorphisms across diverse bovine breeds worldwide. We identified a novel 17-bp deletion within the NR5A2 gene specifically in Chinese Holstein cows (n = 1033) leading to the observation of two genotypes DD and ID. Subsequent association analysis revealed a significant correlation between the ‘ID’ genotype at this locus and a larger number of corpus albicans (p = 0.042) in diestrus, as well as a higher number of mature follicles (p = 0.038) in estrus. In addition, we also found that the distribution of this deletion exhibits strong regionality across different cattle breeds globally. These findings indicate that the 17-bp deletion mutation within the NR5A2 gene is significantly associated with an increased corpus luteum diameter and a greater number of mature follicles, suggesting its potential utility as a valuable DNA marker for enhancing cow fertility.

Published
2024
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2. An upstream deletion polymorphism within the goat Period circadian regulator 1 (PER1) gene was associated with growth traits

Author

Taiyuan Zhang, Chuanying Pan, Yuta Yang, Ke Wang, Haiyu Zhao, and Modian Liu

Subjects
Genetics, endocrine system, Period (gene), IGFBP3, Bioengineering, Biology, PER3, Genotype, Gene family, Animal Science and Zoology, Indel, Gene, Biotechnology, PER1
Abstract

The Period circadian regulator (PER) gene family, including PER1, PER2 and PER3, codes transcriptional repressors which could accurately control biological rhythms. PER1/2 gene was proved to be associated with bone mass and PER1 gene was associated with insulin-like growth factor binding proteins 3 (IGFBP3) levels in serum. However, it was few studies reported genetic effects of PER gene on growth traits at the individual level. In this study, we identified the potential insertion/deletion (indel) loci in PER1/2/3 gene, and then explored the relationship between goat growth traits and the frequency of genotype in Shaanbei white cashmere goats (n = 827). As a result, a 9 bp indel within PER1 gene (g.27528003-27528011 del.TGCTGCTGC; rs642467689) was identified using molecular biology techniques. In addition, there existed significant correlation between the 9 bp indel and body height, height at hip cross, chest depth, body length index and cannon circumference index of goats. These results suggested that the 9 bp indel variation in PER1 gene was associated with goat growth traits, providing the theoretical basic for the role of PER1 gene in goat breeding.

Published
2021
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3. Effects of genetic variations within goatPITX2gene on growth traits and mRNA expression

Author

Chuzhao Lei, Haiyu Zhao, Xianyong Lan, Qing Lin, Hong Chen, Sihuan Zhang, and Chuanying Pan

Subjects
0301 basic medicine, Genetics, medicine.medical_specialty, PITX2, Mrna expression, Animal production, 0402 animal and dairy science, Bioengineering, 04 agricultural and veterinary sciences, Biology, 040201 dairy & animal science, 03 medical and health sciences, 030104 developmental biology, Molecular genetics, PITX2 Gene, Genetic variation, medicine, Homeobox, Animal Science and Zoology, Gene, Biotechnology
Abstract

Paired-like homeodomain 2 (PITX2), a key gene in hypothalamic-pituitary-adrena axis, influences animal growth and development. The objective of this study was to identify the association of the fun...

Published
2019
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4. Effects of genetic variations within goat

Author

Sihuan, Zhang, Haiyu, Zhao, Chuzhao, Lei, Chuanying, Pan, Hong, Chen, Qing, Lin, and Xianyong, Lan

Subjects
Homeodomain Proteins, Gene Expression Regulation, Genotype, Goats, Animals, Genetic Variation, Tissue Distribution, RNA, Messenger, Transcription Factors
Abstract

Paired-like homeodomain 2 (

Published
2019

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