1. Efficacy of Short-Term High-Dose Atorvastatin for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography
- Author
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Recai Alemdar, Ismail Erden, Subhan Yalcin, Serkan Ordu, Hakan Özhan, Cengiz Basar, Onur Caglar, and Mesut Aydin
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Adult ,Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Atorvastatin ,Contrast-induced nephropathy ,Urology ,Contrast Media ,Renal function ,Coronary Angiography ,Nephropathy ,chemistry.chemical_compound ,medicine ,Humans ,Pyrroles ,Creatinine ,business.industry ,atorvastatin ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,N-acetylcysteine ,Acetylcysteine ,Surgery ,Regimen ,chemistry ,Heptanoic Acids ,contrast-induced nephropathy ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Glomerular Filtration Rate ,medicine.drug ,Kidney disease - Abstract
WOS: 000281677000014 PubMed: 20395226 Contrast-induced nephropathy (CIN) is associated with increased morbidity, extended hospital stay, and higher costs. We compared an atorvastatin plus N-acetylcysteine (NAC) regimen with NAC alone in patients undergoing coronary angiography. A total of 130 patients (mean age 54 +/- 10; 77 men) undergoing coronary angiography were studied. Seven CIN cases occurred in the NAC group and 2 in the atorvastatin + NAC group; this difference was not significant. Baseline mean creatinine and estimated glomerular filtration rate (eGFR) were similar between the 2 groups, whereas after the procedure there was a significant creatinine decrease and eGFR increase in the atorvastatin + NAC group. Change in creatinine (baseline creatinine-creatinine after the procedure) was also significantly higher in patients taking statin plus NAC. Atorvastatin may be effective in protecting patients undergoing coronary angiography from CIN.
- Published
- 2010
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