1. The Roles of Oxidized Low-Density Lipoprotein and Interleukin-6 Levels in Acute Atherothrombotic and Lacunar Ischemic Stroke
- Author
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Sibel Guldiken, Yahya Çelik, Baburhan Guldiken, Nilda Turgut, Armagan Tugrul, Muzaffer Demir, Ender Arikan, and Burhan Turgut
- Subjects
Male ,medicine.medical_specialty ,Systole ,Blood Pressure ,medicine.disease_cause ,Gastroenterology ,Brain Ischemia ,Brain ischemia ,Internal medicine ,medicine ,Humans ,Interleukin 6 ,Stroke ,Aged ,biology ,Interleukin-6 ,Cerebral infarction ,business.industry ,Vascular disease ,Middle Aged ,Intracranial Arteriosclerosis ,medicine.disease ,Thrombosis ,Surgery ,Lipoproteins, LDL ,Cholesterol ,Case-Control Studies ,biology.protein ,Female ,Intracranial Thrombosis ,Cardiology and Cardiovascular Medicine ,business ,Oxidative stress ,Lipoprotein - Abstract
The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated. The study consisted of 28 patients with acute ischemic stroke and 23 control subjects. Patients were subdivided into large-vessel (n = 12) and small-vessel (n =16) disease stroke groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The means of oxidized low-density lipoprotein and interleukin-6 levels of patients with acute ischemic stroke were higher than controls ( P < .01, P < .05). Mean oxidized low-density lipoprotein level was higher in the large-vessel disease group than in the small-vessel disease group ( P < .01). The mean of inteleukin-6 levels was higher in the small-vessel disease group ( P < .01). The results of the present study showed that oxidative stress promotes large-vessel disease rather than small-vessel disease stroke, and inflammation may play important an role in the development of small-vessel disease stroke.
- Published
- 2008
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