1. The role of the fibrinolytic system in corneal angiogenesis.
- Author
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Vogten JM, Reijerkerk A, Meijers JC, Voest EE, Borel Rinkes IH, and Gebbink MF
- Subjects
- Animals, Carboxypeptidase B2 deficiency, Carboxypeptidase B2 genetics, Carboxypeptidase B2 pharmacology, Carboxypeptidase B2 physiology, Fibroblast Growth Factor 2 pharmacology, Mice, Mice, Knockout, Plasminogen deficiency, Plasminogen genetics, Plasminogen pharmacology, Plasminogen physiology, Plasminogen Activator Inhibitor 1 deficiency, Plasminogen Activator Inhibitor 1 genetics, Plasminogen Activator Inhibitor 1 pharmacology, Plasminogen Activator Inhibitor 1 physiology, Plasminogen Activators deficiency, Plasminogen Activators genetics, Plasminogen Activators physiology, Tissue Plasminogen Activator deficiency, Tissue Plasminogen Activator genetics, Tissue Plasminogen Activator pharmacology, Tissue Plasminogen Activator physiology, Urokinase-Type Plasminogen Activator deficiency, Urokinase-Type Plasminogen Activator genetics, Urokinase-Type Plasminogen Activator pharmacology, Urokinase-Type Plasminogen Activator physiology, Cornea blood supply, Cornea metabolism, Fibrinolysis, Neovascularization, Physiologic drug effects, Plasminogen Activators pharmacology
- Abstract
The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins involved in the regulation of fibrinolysis during corneal angiogenesis, we have studied corneal vessel formation in mice deficient for urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), plasminogen, plasminogen activator inhibitor-1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI). Our results corroborate earlier findings that angiogenesis in the mouse cornea is dependent on PAI-1 and plasminogen. The absence of tPA, uPA or TAFI did not affect the formation of new vessels in the cornea.
- Published
- 2003
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