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Your search keyword '"Xu, Jing‐Juan"' showing total 19 results
Start Over Author "Xu, Jing‐Juan" Journal angewandte chemie international edition
19 results on '"Xu, Jing‐Juan"'

3. Cascade In Situ Self‐Assembly and Bioorthogonal Reaction Enable the Enrichment of Photosensitizers and Carbonic Anhydrase Inhibitors for Pretargeted Cancer Theranostics.

Author

Wen, Xidan, Zeng, Wenhui, Zhang, Junya, Liu, Yili, Miao, Yinxing, Liu, Shaohai, Yang, Yanling, Xu, Jing‐Juan, and Ye, Deju

Subjects
CARBONIC anhydrase inhibitors, CARBONIC anhydrase, COMPANION diagnostics, ALKALINE phosphatase, MAGNETIC nanoparticles
Abstract

We report here a tumor‐pretargted theranostic approach for multimodality imaging‐guided synergistic cancer PDT by cascade alkaline phosphatase (ALP)‐mediated in situ self‐assembly and bioorthogonal inverse electron demand Diels–Alder (IEDDA) reaction. Using the enzymatic catalysis of ALP that continuously catalyses the dephosphorylation and self‐assembly of trans‐cyclooctene (TCO)‐bearing P‐FFGd‐TCO, a high density of fluorescent and magnetic TCO‐containing nanoparticles (FMNPs‐TCO) can be synthesized and retained on the membrane of tumor cells. They can act as 'artificial antigens' amenable to concurrently capture lately administrated tetrazine (Tz)‐decorated PS (775NP‐Tz) and carbonic anhydrase (CA) inhibitor (SA‐Tz) via the fast IEDDA reaction. This two‐step pretargeting process can further induce FMNPs‐TCO regrowth into microparticles (FMNPs‐775/SA) directly on tumor cell membranes, which is analyzed by bio‐SEM and fluorescence imaging. Thus, efficient enrichment of both SA‐Tz and 775NP‐Tz in tumors can be achieved, allowing to alleviate hypoxia by continuously inhibiting CA activity and improving PDT of tumors. Findings show that subcutaneous HeLa tumors could be completely eradicated and no tumor recurred after irradiation with an 808 nm laser (0.33 W cm−2, 10 min). This pretargeted approach may be applied to enrich other therapeutic agents in tumors to improve targeted therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy.

Author

Zhou, Jie, Yu, Qiao, Song, Juan, Li, Shan, Li, Xiang‐Ling, Kang, Bin K., Chen, Hong‐Yuan, and Xu, Jing‐Juan

Subjects
CANCER treatment, APOPTOSIS, MITOCHONDRIAL proteins, TUMOR growth, COPPER, DISULFIRAM
Abstract

Cuproptosis is a new form of programmed cell death and exhibits enormous potential in cancer treatment. However, reducing the undesirable Cu ion release in normal tissue and maximizing the copper‐induced therapeutic effect in cancer sites are two main challenges. In this study, we constructed a photothermally triggered nanoplatform (Au@MSN‐Cu/PEG/DSF) to realize on‐demand delivery for synergistic therapy. The released disulfiram (DSF) chelated with Cu2+ in situ to generate highly cytotoxic bis(diethyldithiocarbamate)copper (CuET), causing cell apoptosis, and the formed Cu+ species promoted toxic mitochondrial protein aggregation, leading to cell cuproptosis. Synergistic with photothermal therapy, Au@MSN‐Cu/PEG/DSF could effectively kill tumor cells and inhibit tumor growth (inhibition rate up to 80.1 %). These results provide a promising perspective for potential cancer treatment based on cuproptosis, and may also inspire the design of advanced nano‐therapeutic platforms. [ABSTRACT FROM AUTHOR]

Published
2023
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