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Your search keyword '"Sophie Lecomte"' showing total 2 results
Start Over Author "Sophie Lecomte" Journal angewandte chemie international edition
2 results on '"Sophie Lecomte"'

1. PIP2Phospholipid-Induced Aggregation of Tau Filaments Probed by Tip-Enhanced Raman Spectroscopy

Author

Sébastien Bonhommeau, Julien Hunel, Nad'a Lepejova-Caudy, David Talaga, Christophe Cullin, Sophie Lecomte, Laurie Lescos, Willy Smeralda, Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
tip-enhanced Raman spectroscopy, Phospholipid, Peptide, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, symbols.namesake, chemistry.chemical_compound, Amide, [CHIM]Chemical Sciences, Phosphatidylinositol, peptide fibers, Protein secondary structure, phospholipids, chemistry.chemical_classification, General Medicine, Tau filaments, General Chemistry, 021001 nanoscience & nanotechnology, Random coil, 0104 chemical sciences, Membrane, chemistry, symbols, Biophysics, lipids (amino acids, peptides, and proteins), fluorescence, [CHIM.OTHE]Chemical Sciences/Other, 0210 nano-technology, Raman spectroscopy
Abstract

The morphology and secondary structure of peptide fibers formed by aggregation of tubulin-associated unit (Tau) fragments (K18), in the presence of the inner cytoplasmic membrane phosphatidylinositol component (PIP2) or heparin sodium (HS) as cofactors, are determined with nanoscale (

Published
2018
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2. Tip-Enhanced Raman Spectroscopy to Distinguish Toxic Oligomers from Aβ1- 42 Fibrils at the Nanometer Scale

Author

Christophe Cullin, Sébastien Bonhommeau, David Talaga, Sophie Lecomte, and Julien Hunel

Subjects
Scale (anatomy), Chemistry, General Medicine, 02 engineering and technology, General Chemistry, Amyloid fibril, Fibril, Tip-enhanced Raman spectroscopy, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Catalysis, 0104 chemical sciences, symbols.namesake, Crystallography, symbols, Nanometre, Amino acid residue, Raman spectroscopy, 0210 nano-technology
Abstract

For the first time, natural Aβ1–42 fibrils (WT) implicated in Alzheimer's disease, as well as two synthetic mutants forming less toxic amyloid fibrils (L34T) and highly toxic oligomers (oG37C), are chemically characterized at the scale of a single structure using tip-enhanced Raman spectroscopy (TERS). While the proportion of TERS features associated with amino acid residues is similar for the three peptides, a careful examination of amide I and amide III bands allows us to clearly distinguish WT and L34T fibers organized in parallel β-sheets from the small and more toxic oG37C oligomers organized in anti-parallel β-sheets.

Published
2017
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