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Start Over Author "Shen, Zhiqiang" Journal angewandte chemie international edition
10 results on '"Shen, Zhiqiang"'

9. Orchestrating Nitric Oxide and Carbon Monoxide Signaling Molecules for Synergistic Treatment of MRSA Infections.

Author

Gao, Lei, Cheng, Jian, Shen, Zhiqiang, Zhang, Guoying, Liu, Shiyong, and Hu, Jinming

Subjects
CARBON monoxide, METHICILLIN-resistant staphylococcus aureus, NITRIC oxide, BACTERIAL cell walls, CARBON oxides, GRAM-positive bacteria
Abstract

The local delivery of gaseous signaling molecules (GSMs) has shown promising therapeutic potential. However, although GSMs have a subtle interplay in physiological and pathological conditions, the co‐delivery of different GSMs for therapeutic purposes remains unexplored. Herein, we covalently graft a nitric oxide (NO)‐releasing N‐nitrosamine moiety onto the carbon monoxide (CO)‐releasing 3‐hydroxyflavone (3‐HF) antenna, resulting in the first NO/CO‐releasing donor. Under visible light irradiation, photo‐mediated co‐release of NO and CO reveals a superior antimicrobial effect toward Gram‐positive bacteria with a combination index of 0.053. The synergy of NO and CO hyperpolarizes and permeabilizes bacterial membranes, which, however, shows negligible hemolysis and no evident toxicity toward normal mammalian cells. Moreover, the co‐release of NO and CO can efficiently treat MRSA infection in a murine skin wound model, showing a better therapeutic capacity than vancomycin. [ABSTRACT FROM AUTHOR]

Published
2022
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