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Start Over Author "Michael R. Wood" Journal angewandte chemie international edition
2 results on '"Michael R. Wood"'

1. Nonconventional Stereochemical Issues in the Design of the Synthesis of the Vancomycin Antibiotics: Challenges Imposed by Axial and Nonplanar Chiral Elements in the Heptapeptide Aglycons

Author

Michael R. Wood, B. Wesley Trotter, Christopher J. Dinsmore, Jeffrey L. Katz, Timothy I. Richardson, David A. Evans, and Paul S. Watson

Subjects
Atropisomer, Eremomycin, medicine.drug_class, Chemistry, Stereochemistry, Antibiotics, General Chemistry, biochemical phenomena, metabolism, and nutrition, Combinatorial chemistry, Catalysis, Glycopeptide, Axial chirality, medicine, Vancomycin, Chirality (chemistry), medicine.drug
Abstract

Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment of infections by methicillin-resistant Staphylococcus aureus. The first total syntheses of the vancomycin and eremomycin aglycons provide insight into the influence of structure on kinetic and thermodynamic control of atropselective macrocyclizations.

Published
1998
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2. Total Syntheses of Vancomycin and Eremomycin Aglycons

Author

Timothy I. Richardson, Michael R. Wood, B. Wesley Trotter, Jeffrey L. Katz, David A. Evans, and James C. Barrow

Subjects
Eremomycin, medicine.drug_class, Chemistry, Stereochemistry, Antibiotics, Total synthesis, General Chemistry, biochemical phenomena, metabolism, and nutrition, medicine.disease_cause, Combinatorial chemistry, Catalysis, Glycopeptide, Staphylococcus aureus, Axial chirality, medicine, Vancomycin, medicine.drug
Abstract

Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment of infections by methicillin-resistant Staphylococcus aureus. The first total syntheses of the vancomycin and eremomycin aglycons provide insight into the influence of structure on kinetic and thermodynamic control of atropselective macrocyclizations.

Published
1998
Full Text
View/download PDF

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