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Start Over Author "Melot, Romain" Journal angewandte chemie international edition
3 results on '"Melot, Romain"'

3. Palladium-Catalyzed C(sp2)−H Alkylation of Aldehyde-Derived Hydrazones with Functionalized Difluoromethyl Bromides.

Author

Prieto, Alexis, Melot, Romain, Bouyssi, Didier, and Monteiro, Nuno

Subjects
*HYDRAZONES, *ALDEHYDES, *PALLADIUM catalysts, *ALKYLATION, *DIFLUOROMETHYL compounds, *BROMIDES, *CARBON-hydrogen bonds
Abstract

A palladium-catalyzed C(sp2)−H difluoromethylation of aldehyde-derived hydrazones using bromodifluoromethylated compounds to afford the corresponding functionalized difluoromethylketone hydrazones has been established. It is proposed that a radical/SET mechanism proceeding via a difluoroalkyl radical may be involved in the catalytic cycle. Applications of the methodology to the synthesis of α,α-difluoro-β-ketoesters and α,α-difluoroketones (RCOCF2H) have been illustrated. [ABSTRACT FROM AUTHOR]

Published
2016
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