1. Regio- and Stereoselective Oxidative Phenol Coupling inAspergillus niger
- Author
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Wolfgang Hüttel, Axel A. Brakhage, Michael Müller, Christian Gil Girol, Stefan Günther, Thorsten Heinekamp, Jörn Piel, and Katja M. Fisch
- Subjects
Models, Molecular ,Oxidative Coupling ,biology ,Stereochemistry ,Aspergillus niger ,Stereoisomerism ,General Chemistry ,biology.organism_classification ,Catalysis ,Coupling reaction ,chemistry.chemical_compound ,Polyketide ,Phenols ,chemistry ,Coumarins ,Polyketides ,Stereoselectivity ,Oxidative coupling of methane ,Homology modeling - Abstract
Piecing it together: Aspergillus niger produces kotanin by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction.
- Published
- 2012