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Your search keyword '"Feng, Xinxin"' showing total 8 results
Start Over Author "Feng, Xinxin" Journal angewandte chemie international edition
8 results on '"Feng, Xinxin"'

1. Cover Picture: Structure and Function of a “Head-to-Middle” Prenyltransferase: Lavandulyl Diphosphate Synthase (Angew. Chem. Int. Ed. 15/2016)

Author

Liu, Meixia, primary, Chen, Chun-Chi, additional, Chen, Lu, additional, Xiao, Xiansha, additional, Zheng, Yingying, additional, Huang, Jian-Wen, additional, Liu, Weidong, additional, Ko, Tzu-Ping, additional, Cheng, Ya-Shan, additional, Feng, Xinxin, additional, Oldfield, Eric, additional, Guo, Rey-Ting, additional, and Ma, Yanhe, additional

Published
2016
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2. Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5

Author

Zhang, Lilan, primary, Chen, Chun-Chi, additional, Ko, Tzu-Ping, additional, Huang, Jian-Wen, additional, Zheng, Yingying, additional, Liu, Weidong, additional, Wang, Iren, additional, Malwal, Satish R., additional, Feng, Xinxin, additional, Wang, Ke, additional, Huang, Chun-Hsiang, additional, Hsu, Shang-Te Danny, additional, Wang, Andrew H.-J., additional, Oldfield, Eric, additional, and Guo, Rey-Ting, additional

Published
2016
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4. Cover Picture: Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD+, NADPH, or NAD+/10‐Oxogeranial: Reaction Mechanisms (Angew. Chem. Int. Ed. 51/2015)

Author

Hu, Yumei, primary, Liu, Weidong, additional, Malwal, Satish R., additional, Zheng, Yingying, additional, Feng, Xinxin, additional, Ko, Tzu‐Ping, additional, Chen, Chun‐Chi, additional, Xu, Zhongxia, additional, Liu, Meixia, additional, Han, Xu, additional, Gao, Jian, additional, Oldfield, Eric, additional, and Guo, Rey‐Ting, additional

Published
2015
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5. Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD + , NADPH, or NAD + /10‐Oxogeranial: Reaction Mechanisms

Author

Hu, Yumei, primary, Liu, Weidong, additional, Malwal, Satish R., additional, Zheng, Yingying, additional, Feng, Xinxin, additional, Ko, Tzu‐Ping, additional, Chen, Chun‐Chi, additional, Xu, Zhongxia, additional, Liu, Meixia, additional, Han, Xu, additional, Gao, Jian, additional, Oldfield, Eric, additional, and Guo, Rey‐Ting, additional

Published
2015
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6. Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD+, NADPH, or NAD+/10-Oxogeranial: Reaction Mechanisms.

Author

Hu, Yumei, Liu, Weidong, Malwal, Satish R., Zheng, Yingying, Feng, Xinxin, Ko, Tzu ‐ Ping, Chen, Chun ‐ Chi, Xu, Zhongxia, Liu, Meixia, Han, Xu, Gao, Jian, Oldfield, Eric, and Guo, Rey ‐ Ting

Subjects
IRIDOIDS, SYNTHASES, NICOTINAMIDE adenine dinucleotide phosphate, RING formation (Chemistry), PROTONS
Abstract

Structures of the iridoid synthase nepetalactol synthase in the presence of NAD+, NADPH or NAD+/10- oxogeranial were solved. The 10-oxogeranial substrate binds in a transoid-O1-C3 conformation and can be reduced by hydride addition to form the byproduct S-10-oxo-citronellal. Tyr178 Oζ is positioned 2.5 &#197 from the substrate O1 and provides the second proton required for reaction. Nepetalactol product formation requires rotation about C1–C2 to form the cisoid isomer, leading to formation of the cis-enolate, together with rotation about C4–C5, which enables cyclization and lactol production. The structure is similar to that of progesterone-5β-reductase, with almost identical positioning of NADP, Lys146- (147), Tyr178(179), and F342(343), but only Tyr178 and Phe342 appear to be essential for activity. The transoid 10- oxogeranial structure also serves as a model for β-face hydride attack in progesterone 5β-reductases and is of general interest in the context of asymmetric synthesis. [ABSTRACT FROM AUTHOR]

Published
2015
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7. Back Cover: Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes (Angew. Chem. Int. Ed. 17/2012)

Author

Ren, Feifei, primary, Ko, Tzu-Ping, additional, Feng, Xinxin, additional, Huang, Chun-Hsiang, additional, Chan, Hsiu-Chien, additional, Hu, Yumei, additional, Wang, Ke, additional, Ma, Yanhe, additional, Liang, Po-Huang, additional, Wang, Andrew H.-J., additional, Oldfield, Eric, additional, and Guo, Rey-Ting, additional

Published
2012
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