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Start Over Author "Cheng, Ya ‐ Shan" Journal angewandte chemie international edition
6 results on '"Cheng, Ya ‐ Shan"'

1. “Head‐to‐Middle” and “Head‐to‐Tail” cis ‐Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

Author

Gao, Jian, primary, Ko, Tzu‐Ping, additional, Chen, Lu, additional, Malwal, Satish R., additional, Zhang, Jianan, additional, Hu, Xiangying, additional, Qu, Fiona, additional, Liu, Weidong, additional, Huang, Jian‐Wen, additional, Cheng, Ya‐Shan, additional, Chen, Chun‐Chi, additional, Yang, Yunyun, additional, Zhang, Yonghui, additional, Oldfield, Eric, additional, and Guo, Rey‐Ting, additional

Published
2018
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2. Inside Back Cover: “Head‐to‐Middle” and “Head‐to‐Tail” cis ‐Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase (Angew. Chem. Int. Ed. 3/2018)

Author

Gao, Jian, primary, Ko, Tzu‐Ping, additional, Chen, Lu, additional, Malwal, Satish R., additional, Zhang, Jianan, additional, Hu, Xiangying, additional, Qu, Fiona, additional, Liu, Weidong, additional, Huang, Jian‐Wen, additional, Cheng, Ya‐Shan, additional, Chen, Chun‐Chi, additional, Yang, Yunyun, additional, Zhang, Yonghui, additional, Oldfield, Eric, additional, and Guo, Rey‐Ting, additional

Published
2018
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3. Cover Picture: Structure and Function of a “Head-to-Middle” Prenyltransferase: Lavandulyl Diphosphate Synthase (Angew. Chem. Int. Ed. 15/2016)

Author

Liu, Meixia, primary, Chen, Chun-Chi, additional, Chen, Lu, additional, Xiao, Xiansha, additional, Zheng, Yingying, additional, Huang, Jian-Wen, additional, Liu, Weidong, additional, Ko, Tzu-Ping, additional, Cheng, Ya-Shan, additional, Feng, Xinxin, additional, Oldfield, Eric, additional, Guo, Rey-Ting, additional, and Ma, Yanhe, additional

Published
2016
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5. “Head‐to‐Middle” and “Head‐to‐Tail” <italic>cis</italic>‐Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.

Author

Gao, Jian, Ko, Tzu‐Ping, Chen, Lu, Malwal, Satish R., Zhang, Jianan, Hu, Xiangying, Qu, Fiona, Liu, Weidong, Huang, Jian‐Wen, Cheng, Ya‐Shan, Chen, Chun‐Chi, Yang, Yunyun, Zhang, Yonghui, Oldfield, Eric, and Guo, Rey‐Ting

Subjects
DIMETHYLALLYLTRANSTRANSFERASE, PYROPHOSPHATES, X-ray crystallography, ANTIBIOTICS, ADENOSINE synthesis
Abstract

Abstract: We report the first X‐ray crystallographic structure of the “head‐to‐middle” prenyltransferase, isosesquilavandulyl diphosphate synthase, involved in biosynthesis of the merochlorin class of antibiotics. The protein adopts the ζ or cis‐prenyl transferase fold but remarkably, unlike tuberculosinol adenosine synthase and other cis‐prenyl transferases (e.g. cis‐farnesyl, decaprenyl, undecaprenyl diphosphate synthases), the large, hydrophobic side chain does not occupy a central hydrophobic tunnel. Instead, it occupies a surface pocket oriented at 90° to the hydrophobic tunnel. Product chain‐length control is achieved by squeezing out the ligand from the conventional allylic S1 binding site, with proton abstraction being achieved using a diphosphate‐Asn‐Ser relay. The structures revise and unify our thinking as to the mechanism of action of many other prenyl transferases and may also be of use in engineering new merochlorin‐class antibiotics. [ABSTRACT FROM AUTHOR]

Published
2018
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6. Inside Back Cover: “Head‐to‐Middle” and “Head‐to‐Tail” <italic>cis</italic>‐Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase (Angew. Chem. Int. Ed. 3/2018).

Author

Gao, Jian, Ko, Tzu‐Ping, Chen, Lu, Malwal, Satish R., Zhang, Jianan, Hu, Xiangying, Qu, Fiona, Liu, Weidong, Huang, Jian‐Wen, Cheng, Ya‐Shan, Chen, Chun‐Chi, Yang, Yunyun, Zhang, Yonghui, Oldfield, Eric, and Guo, Rey‐Ting

Subjects
ISOPRENYLATION, PYROPHOSPHATES
Published
2018
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