1. Diborodichloromethane as Versatile Reagent for Chemodivergent Synthesis of gem-Diborylalkanes.
- Author
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Fang T, Wang L, Wu M, Qi X, and Liu C
- Abstract
The development of boron reagents is crucial for synthetic chemistry. Herein, we present a scalable and practical synthesis of diborodichloromethane (DBDCM) through the reaction of trichloromethyllithium with bis(pinacolato)diboron (B
2 pin2 ). The resulting DBDCM reagent serves as a basic synthetic unit for the construction of various structurally diverse gem-diborylalkanes through controllable C-Cl functionalizations. Moreover, we have developed consecutive tetra-functionalizations of DBDCM for the construction of diverse tertiary and quaternary carbon containing molecules. The use of isotopically enriched13 C-chloroform and10 B2 pin2 enables the synthesis of isotopically enriched13 C-DBDCM and10 B-DBDCM reagents, which are beneficial for the convenient synthesis of carbon-13 and boron-10 molecules., (© 2023 Wiley-VCH GmbH.)- Published
- 2024
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