1. N
- Author
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Maksim V, Sednev, Volodymyr, Mykhailiuk, Priyanka, Choudhury, Julia, Halang, Katherine E, Sloan, Markus T, Bohnsack, and Claudia, Höbartner
- Subjects
RNA Cleavage ,Adenosine ,Base Sequence ,Nucleic Acid Conformation ,RNA ,DNA, Catalytic ,Methylation ,Substrate Specificity - Abstract
Deoxyribozymes are synthetic enzymes made of DNA that can catalyze the cleavage or formation of phosphodiester bonds and are useful tools for RNA biochemistry. Herein, we report new RNA-cleaving deoxyribozymes to interrogate the methylation status of target RNAs, thereby providing an alternative method for the biochemical validation of RNA methylation sites containing N
- Published
- 2018