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Your search keyword '"Yin, Xia"' showing total 13 results
Start Over Author "Yin, Xia" Journal angewandte chemie
13 results on '"Yin, Xia"'

6. Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation.

Author

Li, Jin, Zhao, Na, Zhang, Wei, Li, Ping, Yin, Xia, Zhang, Wen, Wang, Hui, and Tang, Bo

Subjects
FLUORESCENCE, ATHEROSCLEROTIC plaque, ATHEROSCLEROSIS, PHOSPHORYLATION, VASCULAR endothelium
Abstract

The inflammatory microenvironment involves changes in pH and protein phosphorylation state and is closely related to the occurrence and development of atherosclerosis (AS). Herein, we constructed a dual‐detection fluorescence nanosensor PCN‐NP‐HPZ based on post modification of MOFs, which realized the simultaneous detection and imaging of pH and phosphorylation through the pH‐sensitive group piperazine and the ZrIV node of the MOFs. The sensors were used to monitor changes in blood pH and phosphate levels at different time stages during atherosclerotic plaque formation. Two‐photon fluorescence imaging was also performed in the vascular endothelium. Blood tests combined with two‐photon fluorescence images indicated that in the early stage of AS, blood and tissue pH levels were lower than that of the normal mice, while phosphate and tissue phosphorylation levels were higher than that of the normal mice. The present study provides a new analysis method for the assessment of early atherosclerotic disease. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Enantioselective Nickel‐Catalyzed C(sp3)−H Activation of Formamides.

Author

Wang, Yin‐Xia, Zhang, Feng‐Ping, Chen, Hao, Li, Yue, Li, Jiang‐Fei, and Ye, Mengchun

Subjects
*PHOSPHINE oxides, *BIMETALLIC catalysts, *LAMINATED metals, *HETEROCYCLIC compounds, *PHOSPHINE
Abstract

Enantioselective Ni‐catalyzed C(sp3)−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp3)−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95 % yield and 70–95 % ee. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes

Author

Yi-Mei Wu, Yan-Long Zheng, Yin-Xia Wang, Yan-Yao Liu, Yu-Tong Lin, and Mengchun Ye

Subjects
chemistry.chemical_classification, Alkene, Hydride, 010405 organic chemistry, Aryl, Regioselectivity, General Chemistry, General Medicine, 010402 general chemistry, Aldehyde, 01 natural sciences, Catalysis, Coupling reaction, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Organic chemistry, Alkyl
Abstract

An FeBr3 -catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With (i) PrOH as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α-olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity.

Published
2016

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