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Start Over Author "Qinglong An" Journal angewandte chemie
31 results on '"Qinglong An"'

4. In Situ Real‐Time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self‐Assemblies by Super‐Resolution Imaging

Author

Qinglong Qiao, Wenjuan Liu, Yinchan Zhang, Jie Chen, Guangying Wang, Yi Tao, Lu Miao, Wenchao Jiang, Kai An, and Zhaochao Xu

Subjects
Microscopy, General Chemistry, General Medicine, Catalysis, Single Molecule Imaging, Fluorescent Dyes
Abstract

The visualization of self-assembled structure and dynamics at the molecular level has become a powerful method to understand structure-function relationships of self-assembly. Herein, we in situ real-time imaged the dynamic process of benzyl-naphthalimide dyes at the nanoscale and inspected their internal structure with minimum 2.8 nm localization accuracy through single-molecule localization microscopy (SMLM) imaging. We monitored the growth process of three different assemblies in situ, which possessed highly heterogeneous dynamics with different shapes and growth rates. Furthermore, diverse growth rates were also found at different sites in the same assembly. These results highlight the application of super-resolution microscopy techniques for real-time visualization of internal assembled structure and dynamics in situ.

Published
2022
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5. Enantioselective Three‐Component Photochemical 1,4‐Bisalkylation of 1,3‐Butadiene with Pd/Cu Catalysis

Author

Huimin Yu, Qinglong Zhang, and Weiwei Zi

Subjects
Bromides, Butadienes, Esters, Stereoisomerism, General Chemistry, General Medicine, Amino Acids, Palladium, Catalysis
Abstract

Catalysis by excited-state palladium has emerged as an active area of research, but controlling the enantioselectivity remains a challenge. Herein, we report the use of synergistic Pd/Cu catalysis to accomplish the first three-component photochemical 1,4-bisalkylation reactions of 1,3-butadiene. Consequently, α-amino acid esters bearing quaternary stereocenters were expeditiously synthesized from three simple starting materials: an alkyl bromide, butadiene, and an aldimine ester. Experimental and computational investigation of the reaction mechanism confirmed a radical pathway involving catalysis by an excited-state palladium species. The stereochemistry is mainly controlled by the chiral Cu catalyst.

Published
2022
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13. Quantitative Design of Bright Fluorophores and AIEgens by the Accurate Prediction of Twisted Intramolecular Charge Transfer (TICT)

Author

Ning Xu, Wei Zhou, Qinglong Qiao, Wenjuan Liu, Scott McKechnie, Weijie Chi, Da Lyu, Jie Chen, Zhaochao Xu, Qisheng Zhang, Chao Wang, Davin Tan, Xiao-Fang Jiang, and Xiaogang Liu

Subjects
Materials science, Quantitative design, 010405 organic chemistry, Charge (physics), General Chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, Fluorescence, Catalysis, 0104 chemical sciences, Molecular engineering, chemistry.chemical_compound, chemistry, Chemical physics, Intramolecular force, Fluorescent materials, Density functional theory, BODIPY
Abstract

Inhibition of TICT can significantly increase the brightness of fluorescent materials. Accurate prediction of TICT is thus critical for the quantitative design of high-performance fluorophores and AIEgens. TICT of 14 types of popular organic fluorophores were modeled with time-dependent density functional theory (TD-DFT). A reliable and generalizable computational approach for modeling TICT formations was established. To demonstrate the prediction power of our approach, we quantitatively designed a boron dipyrromethene (BODIPY)-based AIEgen which exhibits (almost) barrierless TICT rotations in monomers. Subsequent experiments validated our molecular design and showed that the aggregation of this compound turns on bright emissions with ca. 27-fold fluorescence enhancement, as TICT formation is inhibited in molecular aggregates.

Published
2020
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14. An Acid‐Regulated Self‐Blinking Fluorescent Probe for Resolving Whole‐Cell Lysosomes with Long‐Term Nanoscopy

Author

Qinglong Qiao, Wenjuan Liu, Jie Chen, Xia Wu, Fei Deng, Xiangning Fang, Ning Xu, Wei Zhou, Shaowei Wu, Wenting Yin, Xiaogang Liu, and Zhaochao Xu

Subjects
Blinking, Humans, General Chemistry, General Medicine, Hydrogen-Ion Concentration, Lysosomes, Catalysis, Fluorescent Dyes, HeLa Cells
Abstract

Long-term super-resolution imaging appears to be increasingly important for unraveling organelle dynamics at the nanoscale, but is challenging due to the need for highly photostable and environment-sensitive fluorescent probes. Here, we report a self-blinking fluorophore that achieved 12 nm spatial resolution and 20 ms time resolution under acidic lysosomal conditions. This fluorophore was successfully applied in super-resolution imaging of lysosomal dynamics over 40 min. The pH dependence of the dye during blinking made the fluorophore sensitive to lysosomal pH. This probe enables simultaneous dynamic and pH recognition of all lysosomes in the entire cell at the single-lysosome-resolved level, which allowed us to resolve whole-cell lysosome subpopulations based on lysosomal distribution, size, and luminal pH. We also observed a variety of lysosome movement trajectories and different types of interactions modes between lysosomes.

Published
2022
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23. Quantitative Design of Bright Fluorophores and AIEgens by the Accurate Prediction of Twisted Intramolecular Charge Transfer (TICT)

Author

Wang, Chao, primary, Qiao, Qinglong, additional, Chi, Weijie, additional, Chen, Jie, additional, Liu, Wenjuan, additional, Tan, Davin, additional, McKechnie, Scott, additional, Lyu, Da, additional, Jiang, Xiao‐Fang, additional, Zhou, Wei, additional, Xu, Ning, additional, Zhang, Qisheng, additional, Xu, Zhaochao, additional, and Liu, Xiaogang, additional

Published
2020
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25. Descriptor ΔGC‐O Enables the Quantitative Design of Spontaneously Blinking Rhodamines for Live‐Cell Super‐Resolution Imaging.

Author

Chi, Weijie, Qiao, Qinglong, Wang, Chao, Zheng, Jiazhu, Zhou, Wei, Xu, Ning, Wu, Xia, Jiang, Xiao, Tan, Davin, Xu, Zhaochao, and Liu, Xiaogang

Subjects
*HIGH resolution imaging, *PHOTOCHROMIC materials, *FORECASTING
Abstract

Herein, we reported a simple, fast, and quantitative theoretical descriptor ΔGC‐O that allows accurate predictions of a wide range of spontaneously blinking rhodamines. ΔGC‐O denotes the Gibbs free energy differences between the closed and open forms of rhodamines and has a good linear relationship with experimental pKcycl values. This correlation affords an effective guide for the quantitative designs of spontaneously blinking rhodamines and eliminates trial‐and‐error. We have validated the predictive power of ΔGC‐O via the development of two spontaneously blinking rhodamines of different colors and enhanced brightness. We also demonstrated their super‐resolution imaging utilities in dynamic live‐cell imaging. We expect that ΔGC‐O will greatly facilitate the efficient creations of spontaneously blinking fluorophores and aid the advancements of super‐resolution bioimaging techniques. [ABSTRACT FROM AUTHOR]

Published
2020
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27. Electrochemically Enabled, Nickel-Catalyzed Amination

Author

Li, Chao, primary, Kawamata, Yu, additional, Nakamura, Hugh, additional, Vantourout, Julien C., additional, Liu, Zhiqing, additional, Hou, Qinglong, additional, Bao, Denghui, additional, Starr, Jeremy T., additional, Chen, Jinshan, additional, Yan, Ming, additional, and Baran, Phil S., additional

Published
2017
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31. Pseudohalide-Induced Moisture Tolerance in Perovskite CH3NH3Pb(SCN)2I Thin Films.

Author

Jiang, Qinglong, Rebollar, Dominic, Gong, Jue, Piacentino, Elettra L., Zheng, Chong, and Xu, Tao

Subjects
*PSEUDOHALIDES, *MOISTURE, *PEROVSKITE, *THIN films, *THIOCYANATES, *CHEMICAL decomposition
Abstract

Two pseudohalide thiocyanate ions (SCN−) have been used to replace two iodides in CH3NH3PbI3, and the resulting perovskite material was used as the active material in solar cells. In accelerated stability tests, the CH3NH3Pb(SCN)2I perovskite films were shown to be superior to the conventional CH3NH3PbI3 films as no significant degradation was observed after the film had been exposed to air with a relative humidity of 95 % for over four hours, whereas CH3NH3PbI3 films degraded in less than 1.5 hours. Solar cells based on CH3NH3Pb(SCN)2I thin films exhibited an efficiency of 8.3 %, which is comparable to that of CH3NH3PbI3 based cells fabricated in the same way. [ABSTRACT FROM AUTHOR]

Published
2015
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