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An overall carbon‐neutral CO2 electroreduction requires enhanced conversion efficiency and intensified functionality of CO2‐derived products to balance the carbon footprint from CO2 electroreduction against fixed CO2. A liquid Sn cathode is herein introduced into electrochemical reduction of CO2 in molten salts to fabricate core–shell Sn−C spheres (Sn@C). An in situ generated Li2SnO3/C directs a self‐template formation of Sn@C. Benefitting from the accelerated reaction kinetics from the liquid Sn cathode and the core–shell structure of Sn@C, a CO2‐fixation current efficiency higher than 84 % and a high reversible lithium‐storage capacity of Sn@C are achieved. The versatility of this strategy is demonstrated by other low melting point metals, such as Zn and Bi. This process integrates energy‐efficient CO2 conversion and template‐free fabrication of value‐added metal‐carbon, achieving an overall carbon‐neutral electrochemical reduction of CO2. [ABSTRACT FROM AUTHOR]

Identification of the molecular target(s) of anticancer metal complexes is a formidable challenge since most of them are unstable toward ligand exchange reaction(s) or biological reduction under physiological conditions. Gold(III) meso-tetraphenylporphyrin ( gold-1 a) is notable for its high stability in biological milieux and potent in vitro and in vivo anticancer activities. Herein, extensive chemical biology approaches employing photo-affinity labeling, click chemistry, chemical proteomics, cellular thermal shift, saturation-transfer difference NMR, protein fluorescence quenching, and protein chaperone assays were used to provide compelling evidence that heat-shock protein 60 (Hsp60), a mitochondrial chaperone and potential anticancer target, is a direct target of gold-1 a in vitro and in cells. Structure-activity studies with a panel of non-porphyrin gold(III) complexes and other metalloporphyrins revealed that Hsp60 inhibition is specifically dependent on both the gold(III) ion and the porphyrin ligand. [ABSTRACT FROM AUTHOR]