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Start Over Author "Heffeter, Petra" Journal angewandte chemie
10 results on '"Heffeter, Petra"'

2. Einbau von (Bioaktiven) Äquatorialen Liganden in Platin(IV)‐Komplexe.

Author

Kastner, Alexander, Schueffl, Hemma, Yassemipour, Patrick A., Keppler, Bernhard K., Heffeter, Petra, and Kowol, Christian R.

Subjects
OXALIPLATIN
Abstract

Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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4. Oral Anticancer Heterobimetallic PtIV−AuI Complexes Show High In Vivo Activity and Low Toxicity.

Author

Babu, Tomer, Ghareeb, Hiba, Basu, Uttara, Schueffl, Hemma, Theiner, Sarah, Heffeter, Petra, Koellensperger, Gunda, Metanis, Norman, Gandin, Valentina, Ott, Ingo, Schmidt, Claudia, and Gibson, Dan

Subjects
HETEROBIMETALLIC complexes, TUMOR growth, BODY weight, CELL lines, SELENOCYSTEINE, WEIGHT loss
Abstract

AuI‐carbene and PtIV−AuI‐carbene prodrugs display low to sub‐μM activity against several cancer cell lines and overcome cisplatin (cisPt) resistance. Linking a cisPt‐derived PtIV(phenylbutyrate) complex to a AuI‐phenylimidazolylidene complex 2, yielded the most potent prodrug. While in vivo tests against Lewis Lung Carcinoma showed that the prodrug PtIV(phenylbutyrate)‐AuI‐carbene (7) and the 1 : 1 : 1 co‐administration of cisPt: phenylbutyrate:2 efficiently inhibited tumor growth (≈95 %), much better than 2 (75 %) or cisPt (84 %), 7 exhibited only 5 % body weight loss compared to 14 % for 2, 20 % for cisPt and >30 % for the co‐administration. 7 was much more efficient than 2 at inhibiting TrxR activity in the isolated enzyme, in cells and in the tumor, even though it was much less efficient than 2 at binding to selenocysteine peptides modeling the active site of TrxR. Organ distribution and laser‐ablation (LA)‐ICP‐TOFMS imaging suggest that 7 arrives intact at the tumor and is activated there. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Interfering with Metabolic Profile of Triple‐Negative Breast Cancers Using Rationally Designed Metformin Prodrugs

Author

Babak, Maria V., primary, Chong, Kai Ren, additional, Rapta, Peter, additional, Zannikou, Markella, additional, Tang, Hui Min, additional, Reichert, Lisa, additional, Chang, Meng Rui, additional, Kushnarev, Vladimir, additional, Heffeter, Petra, additional, Meier‐Menches, Samuel M., additional, Lim, Zhi Chiaw, additional, Yap, Jian Yu, additional, Casini, Angela, additional, Balyasnikova, Irina V., additional, and Ang, Wee Han, additional

Published
2021
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7. Innenrücktitelbild: Ein Organoruthenium-Tumortherapeutikum mit unerwartet hoher Selektivität für Plectin (Angew. Chem. 28/2017)

Author

Meier, Samuel M., primary, Kreutz, Dominique, additional, Winter, Lilli, additional, Klose, Matthias H. M., additional, Cseh, Klaudia, additional, Weiss, Tamara, additional, Bileck, Andrea, additional, Alte, Beatrix, additional, Mader, Johanna C., additional, Jana, Samir, additional, Chatterjee, Annesha, additional, Bhattacharyya, Arindam, additional, Hejl, Michaela, additional, Jakupec, Michael A., additional, Heffeter, Petra, additional, Berger, Walter, additional, Hartinger, Christian G., additional, Keppler, Bernhard K., additional, Wiche, Gerhard, additional, and Gerner, Christopher, additional

Published
2017
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8. Ein Organoruthenium-Tumortherapeutikum mit unerwartet hoher Selektivität für Plectin

Author

Meier, Samuel M., primary, Kreutz, Dominique, additional, Winter, Lilli, additional, Klose, Matthias H. M., additional, Cseh, Klaudia, additional, Weiss, Tamara, additional, Bileck, Andrea, additional, Alte, Beatrix, additional, Mader, Johanna C., additional, Jana, Samir, additional, Chatterjee, Annesha, additional, Bhattacharyya, Arindam, additional, Hejl, Michaela, additional, Jakupec, Michael A., additional, Heffeter, Petra, additional, Berger, Walter, additional, Hartinger, Christian G., additional, Keppler, Bernhard K., additional, Wiche, Gerhard, additional, and Gerner, Christopher, additional

Published
2017
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9. Zweifel an einem Dogma: Hydrolyse äquatorialer Liganden von PtIV‐Komplexen unter physiologischen Bedingungen.

Author

Kastner, Alexander, Poetsch, Isabella, Mayr, Josef, Burda, Jaroslav V., Roller, Alexander, Heffeter, Petra, Keppler, Bernhard K., and Kowol, Christian R.

Abstract

Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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