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Your search keyword '"Gellman, Samuel H."' showing total 25 results
Start Over Author "Gellman, Samuel H." Journal angewandte chemie
25 results on '"Gellman, Samuel H."'

5. Differential Effects of β3‐ versus β2‐Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3‐Derived α/β‐Peptides.

Author

Eddinger, Geoffrey A. and Gellman, Samuel H.

Subjects
*AMINO acid residues, *HELICITY (Chemistry), *OLIGOMERS, *ISOMERS, *CIRCULAR dichroism
Abstract

Oligomers containing α‐ and β‐amino acid residues (α/β‐peptides) have been shown to mimic the α‐helical conformation of conventional peptides when the unnatural residues are derived from β3‐amino acids or cyclic β‐amino acids, but the impact of incorporating β2 residues has received little attention. The effects of β2 residues on the conformation and recognition behavior of α/β‐peptides that mimic an isolated α‐helix were investigated. This effort has focused on 26‐mers based on the Bim BH3 domain; a set of isomers with identical α/β backbones that differ only in the placement of certain side chains along the backbone (β3 vs. β2 substitution) was compared. Circular dichroism data suggest that β2 residues can be helix‐destabilizing relative to β3 residues, although the size of this effect seems to depend on side chain identity. Binding data show that β3→β2 substitution at sites that contact a partner protein, Bcl‐xL, can influence affinity in a way that transcends effects on helicity. [ABSTRACT FROM AUTHOR]

Published
2018
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