1. Comprehensive semen examination in patients with cystic fibrosis
- Author
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M. I. Shtaut, L. V. Schileiko, S. A. Repina, S. A. Krasovsky, G. V. Shmarina, T. M. Sorokina, L. F. Kurilo, and V. B. Chernykh
- Subjects
medicine.medical_specialty ,endocrine system ,RD1-811 ,Urology ,immature germ cells ,Obstructive azoospermia ,Semen ,Semen analysis ,urologic and male genital diseases ,Gastroenterology ,male infertility ,seminal vesicles ,Male infertility ,cystic fibrosis ,Internal medicine ,medicine ,meiosis ,Azoospermia ,medicine.diagnostic_test ,business.industry ,Vas deferens ,medicine.disease ,Congenital absence of the vas deferens ,spermatogenesis ,Diseases of the genitourinary system. Urology ,medicine.anatomical_structure ,Reproductive Medicine ,Oligospermia ,ejaculate ,obstructive azoospermia ,Surgery ,RC870-923 ,business ,vas deferens - Abstract
Introduction. Cystic fibrosis (CF) is a common genetic disorder associated with male infertility. Almost all men with CF are infertile due to obstructive azoospermia. The objective is to evaluate semen parameters, excretion of seminal fluid, and spermatogenesis in CF patients. Materials and methods . We examined 44 male CF patients with pancreatic sufficiency (n = 20) and pancreatic insufficiency (n = 24). Standard semen analysis, quantitative karyological analysis of immature germ cells from ejaculate sediment, biochemical semen analysis (fructose, α-glucosidase, citric acid) were performed. Results. Semen analysis diagnosed azoospermia in 77.3 % patients, severe oligozoospermia (< 1 million/ml) and other diagnoses (oligozoospermia, asthenozoospermia, normozoospermia) in 13.6 % and 9.1 % patients, respectively. The signs of obstruction of the vas deferens and aplasia of seminal vesicles were observed in 91 % patients. Azoospermia, oligospermia, pH
- Published
- 2018