1. Sperm cryopreservation and assisted reproductive technology outcome in patients with spinal cord injury
- Author
-
D. Redhead, J. J. Labat, A Reignier, Paul Barrière, Thomas Fréour, Jenna Lammers, C. Splingart, Sophie Mirallié, Le Bihan, Sylvie, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de Médecine et Biologie du Développement et de la Reproduction [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Faculté de Médecine - Université de Nantes, Centre fédératif de pelvi-périnéologie [CHU de Nantes], and Clinique urologique [CHU de Nantes]
- Subjects
Adult ,Male ,medicine.medical_specialty ,endocrine system ,Sperm Retrieval ,Pregnancy Rate ,Reproductive Techniques, Assisted ,Urology ,medicine.medical_treatment ,Population ,030232 urology & nephrology ,Semen ,Biology ,Electroejaculation ,sperm ,Male infertility ,Andrology ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Endocrinology ,assisted reproductive technology ,Pregnancy ,medicine ,Humans ,Sperm Injections, Intracytoplasmic ,education ,reproductive and urinary physiology ,Infertility, Male ,Spinal Cord Injuries ,Retrospective Studies ,Gynecology ,Cryopreservation ,education.field_of_study ,030219 obstetrics & reproductive medicine ,In vitro fertilisation ,Assisted reproductive technology ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,urogenital system ,Pregnancy Outcome ,General Medicine ,medicine.disease ,Sperm ,spinal cord injury ,Female ,in vitro fertilization ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Semen Preservation - Abstract
International audience; This study aimed to describe spinal cord injured patients' semen characteristics before and after cryopreservation, and assisted reproductive technology cycles outcome compared to the infertile population. Data about sperm analysis and assisted reproductive technology (ART) cycles outcomes for 78 men with spinal cord injury referred for sperm cryopreservation between 1998 and 2013 were retrospectively analysed and compared with a reference group consisting of every Intra Cytoplasmic Sperm Injection (ICSI) cycle performed in our in vitro fertilization unit over the 2009-2014 period. Semen was collected by penile vibratory stimulation (PVS), electroejaculation or via testis biopsies. Fresh and frozen semen parameters and ART outcomes with frozen-thawed sperm were measured. Patients were divided into three groups according to the sperm retrieval methods: 37 electroejaculations, 37 PVSs and four surgical sperm retrievals. Low ejaculate volume was observed in 33% of the patients, and oligozoospermia in 37% of the patients. Specimens from 77 of the patients contained motile sperm and were therefore frozen for future use. There was no statistical difference for any of the fresh semen parameters between all groups. Twenty of them underwent ICSI leading to five live births, while four underwent intrauterine insemination. ART with frozen-thawed spermatozoa can provide men with SCI with comparable results as in the infertile population.
- Published
- 2017
- Full Text
- View/download PDF