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Start Over Author "Yunxia Qiao" Journal analytical methods
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1. Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA

Author

Yan Jin, Xiao-Qin Liu, Yuexia Wang, and Yunxia Qiao

Subjects
Telomerase, General Chemical Engineering, General Engineering, Tumor cells, Biology, Electrochemistry, Combinatorial chemistry, Analytical Chemistry, chemistry.chemical_compound, Biochemistry, chemistry, Ferrocene, Telomeric dna, heterocyclic compounds, DNA, G quadruplex binding
Abstract

Ligands that bind and stabilize G-quadruplex DNA structures are of significant interest because of their potential to inhibit telomerase and halt tumor cell proliferation. An electrochemical method was proposed to select natural G-quadruplex-binding ligands using ferrocene as the electrochemical indicator.

Published
2011
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