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Your search keyword '"Hu, Zhiyuan"' showing total 13 results
Start Over Author "Hu, Zhiyuan" Journal analytical chemistry
13 results on '"Hu, Zhiyuan"'

3. Ultrasensitive Gastric Cancer Circulating Tumor Cellular CLDN18.2 RNA Detection Based on a Molecular Beacon

Author

Fan, Linyang, primary, Chong, Xiaoyi, additional, Zhao, Minzhi, additional, Jia, Fei, additional, Wang, Zihua, additional, Zhou, Ying, additional, Lu, Xiao, additional, Huang, Qiongrong, additional, Li, Ping, additional, Yang, Yanlian, additional, Hu, Zhiyuan, additional, Li, Qin, additional, Zhang, Xiaotian, additional, and Shen, Lin, additional

Published
2020
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8. Ultrasensitive Gastric Cancer Circulating Tumor Cellular CLDN18.2RNA Detection Based on a Molecular Beacon

Author

Fan, Linyang, Chong, Xiaoyi, Zhao, Minzhi, Jia, Fei, Wang, Zihua, Zhou, Ying, Lu, Xiao, Huang, Qiongrong, Li, Ping, Yang, Yanlian, Hu, Zhiyuan, Li, Qin, Zhang, Xiaotian, and Shen, Lin

Abstract

Gastric cancer (GC) is a major global cancer burden, and only HER2-targeted therapies have been approved in first line clinical therapy. CLDN18.2 has been regarded as a potential therapeutic target for gastrointestinal tumors, and global clinical trials have been in process. Hence, the precise, efficient, and noninvasive detection of CLDN18.2 expression is important for the effective application of this attractive target. A high similarity of protein sequence between CLDN18.1 and -18.2 made RNA become more suitable for the detection of CLDN18.2 expression. In this study, CLDN18.2 molecular beacon (MB) with a stem-loop hairpin structure was optimized by phosphorothioate and 2′-O-methyl for stability and efficiency. The MB could recognize CLDN18.2RNA rapidly. Its resolution and selectivity has been verified in several model cells, demonstrating that MB can distinguish CLDN18.2 expression in several model cells. Furthermore, it was applied successfully to the circulating tumor cell (CTC) assay. The concordance in the expression of CLDN18.2 between CTCs and tissue biopsy is 100% (negative: 3 vs 3; positive: 7 vs 7), indicating that CLDN18.2RNA detection in CTCs based on a MB will be a promising approach for searching potential patients to CLDN 18.2 targeted drug.

Published
2021
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9. Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor

Author

Wang, Zihua, primary, Wang, Weizhi, additional, Bu, Xiangli, additional, Wei, Zewen, additional, Geng, Lingling, additional, Wu, Yue, additional, Dong, Chengyan, additional, Li, Liqiang, additional, Zhang, Di, additional, Yang, Shu, additional, Wang, Fan, additional, Lausted, Christopher, additional, Hood, Leroy, additional, and Hu, Zhiyuan, additional

Published
2015
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13. Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging

Author

Wang, Weizhi, primary, Li, Menglin, additional, Wei, Zewen, additional, Wang, Zihua, additional, Bu, Xiangli, additional, Lai, Wenjia, additional, Yang, Shu, additional, Gong, He, additional, Zheng, Hui, additional, Wang, Yuqiao, additional, Liu, Ying, additional, Li, Qin, additional, Fang, Qiaojun, additional, and Hu, Zhiyuan, additional

Published
2014
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