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Your search keyword '"Chen, Qingqing"' showing total 5 results
Start Over Author "Chen, Qingqing" Journal analytical chemistry
5 results on '"Chen, Qingqing"'

5. Lysosome-Targeting Red-Emitting Aggregation-Induced Emission Probe with Large Stokes Shift for Light-Up in SituVisualization of β-N-Acetylhexosaminidase

Author

Wang, Qiang, Li, Chunbin, Chen, Qingqing, Zhang, Pengfei, Wang, Dong, Kang, Miaomiao, Jiang, Guoyu, and Wang, Jianguo

Abstract

Lysosomal β-N-acetylhexosaminidase (Hex) has been reported to possess unique physiological performances. Detection and visualization of Hex in lysosome will be favorable to reveal the basis of its functions. However, Hex-specific fluorescent probes are rarely reported. In this study, we reported the first lysosome-targeting Hex-lighting-up aggregation-induced emission (AIE)-active fluorescent probe (GlcNAc-TPE) with remarkably large Stokes shift and high sensitivity and selectivity. GlcNAc-TPE can selectively locate in lysosome and visualize endogenous Hex in live HCT116 cells and in live mice with high stability and good biocompatibility, providing a useful AIE probe for real-time visualization of Hex in live samples.

Published
2019
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