1. Blood ammonia in patients with chronic liver diseases: A better defined role in clinical practice.
- Author
-
Mallet M, Desplats V, Bouzbib C, Sultanik P, Alioua I, Rudler M, Weiss N, and Thabut D
- Subjects
- Brain, Diagnosis, Differential, Humans, Liver Cirrhosis, Ammonia, Hepatic Encephalopathy diagnosis, Hepatic Encephalopathy etiology
- Abstract
Ammonia is one of the main players in the pathogenesis of hepatic encephalopathy (HE) in patients with chronic liver diseases. The usefulness of measuring ammonemia has been debated since many years. New data reveal that besides helping in the differential diagnosis of HE, ammonemia could be a prognostic marker not only in patients with HE, but also in patients without any neurological symptoms, suggesting a potential toxic role of ammonia beyond the brain. Finally, targeting ammonemia while monitoring therapeutic response could be a way to improve outcomes in patients with HE., Competing Interests: Declaration of competing interest Dominique Thabut declares having received consultant fees from MedDay Pharmaceuticals, Gore, Alfasigma and Owkin. Nicolas Weiss declares having received consultant fees from MedDay Pharmaceuticals and Owkin., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF