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A simple, accurate and sensitive visible spectrophotometric method for the determination of nimodipine (NMD) and nitrazepam (NTZ) is described. The method is based on the diazotization of reduced drugs with nitrous acid followed by coupling with resorcinol to form colored azo-dye in an alkaline medium. The resulting colored azo-dye exhibits maximum absorption peak at 480 nm for both NTZ and NMD. Beer's law was obeyed over the concentration ranges 0.5-10 and 1.0-40.0 μg/mL for NTZ and NMD, respectively. The calculated molar absorptivities are 1.84 × 104 and 0.67 × 10-4 L mol-1cm-1 for NTZ and NMD, respectively. All the variables such as effect of acid, alkali and reaction time were studied in order to optimize the reaction conditions. No interference from the excipients added to tablets was found. Statistical analysis of the results using Student's t-test for accuracy and F-test for precision revealed no significant difference between the proposed method and the literature method. The accuracy and validity of the methods were further established by recovery studies through the standard addition technique. [ABSTRACT FROM AUTHOR]

Three simple, sensitive, accurate and indirect visible spectrophotometric methods have been developed for the estimation of lamotrigine (LMT) in both pure and in pharmaceutical preparations. They are based on the oxidation of lamotrigine with a known excess of cerium(IV) in acid medium. The unreacted cerium(IV) oxidize leuco crystal violet to crystal violet colored dye (Method A), leuco malachite green to bluish-green malachite green dye (Method B), leuco xylene cyanol FF to xylene cyanol FF bluish dye (Method C) and exhibiting absorption maxima (λmax) at 580, 610 and 610 nm, respectively. In these methods, the amount of cerium(IV) reacted corresponds to the amount of LMT. The results of the three methods have been validated statistically and by recovery studies. The results obtained in the proposed methods were in good agreement with the label claim. [ABSTRACT FROM AUTHOR]

A novel copper(II) complex of quinolin-4(3H)-one derived Schiff base ligand was synthesized and characterized by elemental analyses, IR, 1H-NMR, MS, UV-Vis, magnetic moments, conductance measurements and thermal studies. The DNA binding and nuclease activities of copper(II) complex was performed. [ABSTRACT FROM AUTHOR]