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Start Over Author "Jóźwiak, J." Journal anaerobe
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2. Fecal lactoferrin and Clostridium spp. in stools of autistic children.

Author

Martirosian G, Ekiel A, Aptekorz M, Wiechuła B, Kazek B, Jankowska-Steifer E, Jóźwiak J, and Moskalewski S

Subjects
Adolescent, Anti-Bacterial Agents pharmacology, Child, Child, Preschool, Female, Humans, Male, Microbial Sensitivity Tests, Autistic Disorder, Bacterial Toxins analysis, Clostridium isolation & purification, Feces chemistry, Feces microbiology, Lactoferrin analysis
Abstract

Stools from autistic and healthy children were studied for fecal lactoferrin, Clostridium difficile toxins, Clostridium perfringens enterotoxin and cultured for Clostridium spp. Elevated level of FLA was demonstrated in 24.4% stools, all from boys (31.25%). No toxins were detected. Clostridium spp. was isolated with similar frequency from all samples. C. perfringens were isolated significantly often from the autistic stools, intermediate sensitive strains to penicillin 19%, to clindamycin 11.3%, and to metronidazole 7.5% were detected. Further studies on fecal microflora and inflammatory mediators, with larger groups of patients, are required in order to explain their role in neurological deficits., (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Published
2011
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