1. Effects of creatine supplementation on muscle wasting and glucose homeostasis in rats treated with dexamethasone
- Author
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Claudia R. da Luz, Antonio Herbert Lancha, Wilson Max Almeida Monteiro de Moraes, Bruno Gualano, Fabiana de Salvi Guimarães, Humberto Nicastro, Vitor de Salles Painelli, Alessandra Medeiros, André dos Santos Costa, and Patricia Chakur Brum
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Clinical Biochemistry ,Biology ,Creatine ,Biochemistry ,Dexamethasone ,Animal data ,chemistry.chemical_compound ,Insulin resistance ,Internal medicine ,medicine ,Animals ,Humans ,Glucose homeostasis ,Muscle, Skeletal ,Wasting ,Glucose Transporter Type 4 ,Drinking Water ,Organic Chemistry ,medicine.disease ,Muscle atrophy ,Rats ,Muscular Atrophy ,Insulin receptor ,Endocrinology ,chemistry ,biology.protein ,Insulin Resistance ,medicine.symptom ,Proto-Oncogene Proteins c-akt ,medicine.drug - Abstract
We aimed to investigate the possible role of creatine (CR) supplementation in counteracting dexamethasone-induced muscle wasting and insulin resistance in rats. Also, we examined whether CR intake would modulate molecular pathways involved in muscle remodeling and insulin signaling. Animals were randomly divided into four groups: (1) dexamethasone (DEX); (2) control pair-fed (CON-PF); (3) dexamethasone plus CR (DEX-CR); and (4) CR pair-fed (CR-PF). Dexamethasone (5 mg/kg/day) and CR (5 g/kg/day) were given via drinking water for 7 days. Plantaris and extensor digitorum longus (EDL) muscles were removed for analysis. Plantaris and EDL muscle mass were significantly reduced in the DEX-CR and DEX groups when compared with the CON-PF and CR-PF groups (P
- Published
- 2011
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