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Start Over Author "A. V. Hakobyan" Journal amino acids
1 results on '"A. V. Hakobyan"'

1. Using the same organocatalyst for asymmetric synthesis of both enantiomers of glutamic acid-derived Ni(II) complexes via 1,4-additions of achiral glycine and dehydroalanine Schiff base Ni(II) complexes

Author

Victor N. Khrustalev, Yuri N. Belokon, M. A. Moskalenko, Zalina T. Gugkaeva, Victor I. Maleev, A. T. Tsaloev, Kiryl K. Babievsky, Karine V. Hakobyan, and Ashot S. Saghyan

Subjects
Alanine, Schiff base, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Glycine, Enantioselective synthesis, Glutamic Acid, Stereoisomerism, Naphthols, Glutamic acid, Biochemistry, Medicinal chemistry, Catalysis, chemistry.chemical_compound, chemistry, Nickel, Dehydroalanine, Michael reaction, Enantiomer, 1-Carboxyglutamic Acid, Schiff Bases
Abstract

(S)- and (R)-BIMBOL were efficient PT catalysts of asymmetric Michael addition of prochiral Ni-PBP-Gly (1) to acrylic esters and malonic esters to Ni-PBP-Δ-Ala (2) correspondingly. The salient feature of the catalysis is opposite configurations of Glu prepared via the two paths with BIMBOL of the same configuration and a perspective novel catalytic procedure for the synthesis of Gla derivatives.

Published
2011
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