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Acute hemorrhagic pancreatitis was created in dogs using the closed duodenal loop technique. After 18 hours, a a constant rate of pancreatic exocrine secretion was stimulated with secretin. A direct relationship was observed between the percentage inhibition of secretin-stimulated pancreatic exocrine flow and the dose of antidiuretic hormone administered to dogs with acute hemorrhagic pancreatitis. The acute hemorrhagic pancreatitis reduced the sensitivity of the exocrine pancreas to secretin and antidiuretic hormone.

Chemoneurolysis of the canine antral submucosa with 25% ethyl alcohol solutions reduced ulcer formation and increased the survival times in animals subjected to the Exalto-Mann-Williamson ulcer-producing procedure.

Innervated (Pavlov) gastric fundic pouches were constructed in dogs. One group of dogs served as controls, and another group of dogs had their pouch submucosa infiltrated with 25 per cent ethyl alcohol. The alcohol infiltration of the gastric pouch submucosa eliminated the gastric secretory responses to histamine, pentagastrin, a meat meal, and insulin-induced hypoglycemia. The alcohol infusion of the gastric pouch submucosa did not modify the elevated serum gastrin levels to a meat meal, alter the basal or stimulated mean splenic arterial blood flow to the pouch, nor alter the histologic appearance of the pouch with hematoxylin and eosin or histochemical fluorescence of catecholamines. Transplantation of 75 per cent of the gastric antrum into the colon caused a basal and a meal-augmented hypergastrinemia in all dogs. In the control Pavlov pouches the hypergastrinemia induced elevated gastric secretory responses to histamine, pentagastrin, and insulin-induced hypoglycemia. In those Pavlov pouches in which the submucosa had been infiltrated with alcohol, the hypergastrinemia could not induce any gastric secretory response to histamine, pentagastrin, or insulin-induced hypoglycemia.

Double denervated gastric pouches were constructed in dogs. One gastric pouch served as a control, and the other gastric pouch had its submucosa infiltrated with 25% ethyl alcohol (submucosal chemoneurolysis). Neurolysis of these gastric pouches did not alter their histological appearance but did eliminate their gastric secretory responses to histamine, meat and pentagastrin. The dogs exhibited elevated serum gastrin levels after feeding.

Antidiuretic hormone had a marked effect on the microscopic anatomy of the pancreas and the duodenum subjected to a closed duodenal loop obstruction. In contrast to the acute hemorrhagic pancreatitis usually seen, the pancreas showed only a slight extravasation of red and white blood cells into the connective tissue spaces, some blood vessel engorgement and a slight edema. No tissue disruption of the pancreas was observed. The appearance of the closed loops were also modified by the antidiuretic hormone. These closed loops contained small amounts of fluid with little odor and the duodenal villi showed little or no necrosis. Antidiuretic hormone also reduced the amylase concentration and the fluid volume in the peritoneal cavity and in the closed duodenal loop.

Infiltration of the gastric fundic submucosa with 25 per cent ethyl alcohol markedly reduces the mean acetylcholinesterase rate of activity in the fundic mucosa and submucosa. This can be considered as evidence for a reduction in the acetylcholine concentration caused by a destruction of the submucosal plexus.

Double denervated gastric pouches were constructed in dogs. One gastric pouch served as a control, and the other gastric pouch had its submucosa infiltrated with 25% ethyl alcohol, (submucosal chemoneurolysis). Neurolysis of these gastric pouches eliminated their gastric secretory responses to histamine, meat and pentagastrin without altering their histological appearance. Transplantation of 75% of the gastric antrum into the colon caused a hypergastrinemia and increased the sensitivity of the control gastric pouches to the various stimuli but had no such effect on those gastric pouches infiltrated with ethyl alcohol.