1. Rapid re-infection with soil-transmitted helminths after triple-dose albendazole treatment of school-aged children in Yunnan, People's Republic of China.
- Author
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Yap P, Du ZW, Wu FW, Jiang JY, Chen R, Zhou XN, Hattendorf J, Utzinger J, and Steinmann P
- Subjects
- Albendazole administration & dosage, Ancylostomatoidea, Animals, Anthelmintics administration & dosage, Ascariasis drug therapy, Ascariasis epidemiology, Ascaris lumbricoides, Child, China epidemiology, Double-Blind Method, Feces parasitology, Female, Helminthiasis epidemiology, Hookworm Infections drug therapy, Hookworm Infections epidemiology, Humans, Male, Parasite Egg Count, Prevalence, Soil parasitology, Strongyloides stercoralis, Strongyloidiasis drug therapy, Strongyloidiasis epidemiology, Treatment Outcome, Trichuriasis drug therapy, Trichuriasis epidemiology, Trichuris, Albendazole therapeutic use, Anthelmintics therapeutic use, Helminthiasis drug therapy
- Abstract
Post-treatment soil-transmitted helminth re-infection patterns were studied as part of a randomized controlled trial among school-aged children from an ethnic minority group in Yunnan province, People's Republic of China. Children with a soil-transmitted helminth infection (N = 194) were randomly assigned to triple-dose albendazole or placebo and their infection status monitored over a 6-month period using the Kato-Katz and Baermann techniques. Baseline prevalence of Trichuris trichiura, Ascaris lumbricoides, hookworm, and Strongyloides stercoralis were 94.5%, 93.3%, 61.3%, and 3.1%, respectively, with more than half of the participants harboring triple-species infections. For the intervention group (N = 99), the 1-month post-treatment cure rates were 96.7%, 91.5%, and 19.6% for hookworm, A. lumbricoides, and T. trichiura, respectively. Egg reduction rates were above 88% for all three species. Rapid re-infection with A. lumbricoides was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and T. trichiura was considerably slower.
- Published
- 2013
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