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Your search keyword '"Schaenman, Joanna"' showing total 4 results
Start Over Author "Schaenman, Joanna" Journal american journal of transplantation
4 results on '"Schaenman, Joanna"'

1. Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Author

Shino, Michael, Todd, Jamie, Neely, Megan, Kirchner, Jerry, Frankel, Courtney, Snyder, Laurie, Pavlisko, Elizabeth, Schaenman, Joanna, Mason, Kristen, Kesler, Karen, Martinu, Tereza, Singer, Lianne, Tsuang, Wayne, Budev, Marie, Shah, Pali, Reynolds, John, Williams, Nikki, Robien, Mark, Palmer, Scott, Weigt, S, Belperio, John, and Fishbein, Gregory

Subjects
cytokines/cytokine receptors, immunobiology, lung (allograft) function/dysfunction, lung failure/injury, lung transplantation/pulmonology, lung transplantation: living donor, pathology/histopathology, rejection: acute, translational research/science, Allografts, Biomarkers, Chemokine CXCL10, Chemokine CXCL9, Graft Rejection, Graft vs Host Disease, Humans, Lung, Lung Transplantation, Prospective Studies
Abstract

Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential propagators of allograft injury. We hypothesized that these chemokines would be quantifiable in plasma, and would associate with subsequent CLAD development. In this prospective multicenter study, we evaluated 721 plasma samples for CXCL9/CXCL10 levels from 184 participants at the time of transbronchial biopsies during their first-year post-transplantation. We determined the association between plasma chemokines, histopathologic injury, and CLAD risk using Cox proportional hazards models. We also evaluated CXCL9/CXCL10 levels in bronchoalveolar lavage (BAL) fluid and compared plasma to BAL with respect to CLAD risk. Plasma CXCL9/CXCL10 levels were elevated during the injury patterns associated with CLAD, acute rejection, and acute lung injury, with a dose-response relationship between chemokine levels and CLAD risk. Importantly, there were strong interactions between injury and plasma CXCL9/CXCL10, where histopathologic injury associated with CLAD only in the presence of elevated plasma chemokines. We observed similar associations and interactions with BAL CXCL9/CXCL10 levels. Elevated plasma CXCL9/CXCL10 during allograft injury may contribute to CLAD pathogenesis and has potential as a minimally invasive immune monitoring biomarker.

Published
2022

2. Frailty and aging‐associated syndromes in lung transplant candidates and recipients

Author

Schaenman, Joanna M, Diamond, Joshua M, Greenland, John R, Gries, Cynthia, Kennedy, Cassie C, Parulekar, Amit D, Rozenberg, Dmitry, Singer, Jonathan P, Singer, Lianne G, Snyder, Laurie D, and Bhorade, Sangeeta

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Organ Transplantation, Transplantation, Lung, Aged, Frail Elderly, Frailty, Humans, Lung Transplantation, Sarcopenia, Syndrome, clinical decision-making, clinical research / practice, complication: medical / metabolic, geriatrics, immunobiology, lung biology, lung transplantation / pulmonology, recipient selection, risk assessment / risk stratification, translational research / science, Medical and Health Sciences, Surgery, Clinical sciences, Immunology
Abstract

Many lung transplant candidates and recipients are older and frailer compared to previous eras. Older patients are at increased risk for pre- and posttransplant mortality, but this risk is not explained by numerical age alone. This manuscript represents the product of the American Society of Transplantation (AST) conference on frailty. Experts in the field reviewed the latest published research on assessment of elderly and frail lung transplant candidates. Physical frailty, often defined as slowness, weakness, low physical activity, shrinking, and exhaustion, and frailty evaluation is an important tool for evaluation of age-associated dysfunction. Another approach is assessment by cumulative deficits, and both types of frailty are common in lung transplant candidates. Frailty is associated with death or delisting before transplant, and may be associated with posttransplant mortality. Sarcopenia, cognitive dysfunction, depression, and nutrition are other important components for patient evaluation. Aging-associated inflammation, telomere dysfunction, and adaptive immune system senescence may also contribute to frailty. Developing tools for frailty assessment and interventions holds promise for improving patient outcomes before and after lung transplantation.

Published
2021

3. HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV

Author

Durand, Christine M., Florman, Sander, Motter, Jennifer D., Brown, Diane, Ostrander, Darin, Yu, Sile, Liang, Tao, Werbel, William A., Cameron, Andrew, Ottmann, Shane, Hamilton, James P., Redd, Andrew D., Bowring, Mary G., Eby, Yolanda, Fernandez, Reinaldo E., Doby, Brianna, Labo, Nazzarena, Whitby, Denise, Miley, Wendell, Friedman‐Moraco, Rachel, Turgeon, Nicole, Price, Jennifer C., Chin‐Hong, Peter, Stock, Peter, Stosor, Valentina, Kirchner, Varvara A., Pruett, Timothy, Wojciechowski, David, Elias, Nahel, Wolfe, Cameron, Quinn, Thomas C., Odim, Jonah, Morsheimer, Megan, Mehta, Sapna A., Rana, Meenakshi M., Huprikar, Shirish, Massie, Allan, Tobian, Aaron A. R., Segev, Dorry L., Pereira, Marcus, Piquant, Dominique, Edwards, Carolyn, Ranganna, Karthik M, Link, Katherine, Pearson, Thomas, Mehta, Aneesh K, Lyon, G. Marshall, Kitchens, William, Huckaby, Jeryl, Elbein, Rivka, Roberson, April, Ferry, Elizabeth, Adebiyi, Margaret, Adebiyi, Oluwafisayo, Kubal, Chandrahekhar, Ambinder, Richard, Barnaba, Brittany, Bismut, Gilad, Bollinger, Juli, Boyarsky, Brian, Charles, Curtisha, Cochran, Willa V, Desai, Niraj N, Doby, Brianna, Johnstone, Jaylyn, Kirby, Charles, Klock, Ethan, Kusemiju, Oyinkansola, Miller, Jernelle, Morrison, Michelle, Prizzi, Michelle, Schmidt, Haley, Rasmussen, Sarah, Sugarman, Jeremy, Seaman, Shanti, Thomas, Margret, Akhran, Aleya, Coakley, Margaret, Cooper, Matthew, Gilbert, Alexander, Stucke, Alyssa, Timpone, Joseph, Castillo‐Lugo, Jose A, Townsend, Melba, Haydel, Brandy M., Goudy, Leah, Gallon, Lorenzo, Dieter, Rebecca, Deterville, Cecilia, Klein, Elizabeth, Neumann, Henry, Weldon, Elaina P, Hand, Jonathan, Smith, Angela R, Blumberg, Emily A, Donaghy, Eileen, Dunn, Ty, Sawinski, Deirdre, Mall, Mark, Santos, Carlos A. Q, Basinger, Katherine, Locke, Jayme E, Mehta, Shikha, Mompoint‐Williams, Darnell, Gadzhyan, Janette, Schaenman, Joanna, Aslam, Saima, Mekeel, Kristin, Nguyen, Phirum, Chao, Ada, Kwan, Joanne, Rogers, Rodney, Srisengf, Tab, Apewokin, Senu, Harrison, Kathleen, Kramer, Samantha, Wilkinson, Rachel, Benamu, Esther, Spaggiari, Mario, Bruno, Kelly, Brogden, Gregory, Husson, Jennifer, Jeffery, Alicia, Marrazzo, Ilise D, Morris, Michele I, Munoz, Carlos, Simkins, Jacques, Farnsworth, Mary, Haidar, Ghady, Hughes Kramer, Kailey, Pakstis, Diana Lynn, Silveira, Fernanda, Baah, Whitney, Carlson, Emily, La Hoz, Ricardo M, Agarwal, Avinash, Doyle, Alden, Nagy, Jamie, Baldecchi, Mary, Brigle, Nathaniel, Gupta, Gaurav, Butkus‐Small, Catherine, Muthukumar, Thangamani, Malinis, Maricar, and Tomlin, Ricarda

Abstract

Liver transplantation (LT) from donors‐with‐HIV to recipients‐with‐HIV (HIV D+/R+) is permitted under the HOPE Act. There are only three international single‐case reports of HIV D+/R+ LT, each with limited follow‐up. We performed a prospective multicenter pilot study comparing HIV D+/R+ to donors‐without‐HIV to recipients‐with‐HIV (HIV D−/R+) LT. We quantified patient survival, graft survival, rejection, serious adverse events (SAEs), human immunodeficiency virus (HIV) breakthrough, infections, and malignancies, using Cox and negative binomial regression with inverse probability of treatment weighting. Between March 2016–July 2019, there were 45 LTs (8 simultaneous liver‐kidney) at 9 centers: 24 HIV D+/R+, 21 HIV D−/R+ (10 D− were false‐positive). The median follow‐up time was 23 months. Median recipient CD4 was 287 cells/µL with 100% on antiretroviral therapy; 56% were hepatitis C virus (HCV)‐seropositive, 13% HCV‐viremic. Weighted 1‐year survival was 83.3% versus 100.0% in D+ versus D− groups (p= .04). There were no differences in one‐year graft survival (96.0% vs. 100.0%), rejection (10.8% vs. 18.2%), HIV breakthrough (8% vs. 10%), or SAEs (all p> .05). HIV D+/R+ had more opportunistic infections, infectious hospitalizations, and cancer. In this multicenter pilot study of HIV D+/R+ LT, patient and graft survival were better than historical cohorts, however, a potential increase in infections and cancer merits further investigation. A multicenter study of HIV+ donor to HIV+ recipient liver transplantation under the HOPE Act shows that patient and graft survival were better than historical cohorts, but the possible increased incidence of infections and cancer merits further investigation.

Published
2022
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4. Report from the American Society of Transplantation on frailty in solid organ transplantation

Author

Kobashigawa, Jon, primary, Dadhania, Darshana, additional, Bhorade, Sangeeta, additional, Adey, Deborah, additional, Berger, Joseph, additional, Bhat, Geetha, additional, Budev, Marie, additional, Duarte-Rojo, Andres, additional, Dunn, Michael, additional, Hall, Shelley, additional, Harhay, Meera N., additional, Johansen, Kirsten L., additional, Joseph, Susan, additional, Kennedy, Cassie C., additional, Kransdorf, Evan, additional, Lentine, Krista L., additional, Lynch, Raymond J., additional, McAdams-DeMarco, Mara, additional, Nagai, Shunji, additional, Olymbios, Michael, additional, Patel, Jignesh, additional, Pinney, Sean, additional, Schaenman, Joanna, additional, Segev, Dorry L., additional, Shah, Palak, additional, Singer, Lianne G., additional, Singer, Jonathan P., additional, Sonnenday, Christopher, additional, Tandon, Puneeta, additional, Tapper, Elliot, additional, Tullius, Stefan G., additional, Wilson, Michael, additional, Zamora, Martin, additional, and Lai, Jennifer C., additional

Published
2019
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