1. Microcirculation Inflammation Associates With Outcome in Renal Transplant Patients With De Novo Donor-Specific Antibodies
- Author
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H. T. Cook, Kathy Dominy, Kakit Chan, Jack Galliford, Candice Roufosse, David Taube, Paul Brookes, H. de Kort, Adam McLean, Eva Santos-Nunez, and Michelle Willicombe
- Subjects
Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,Biopsy ,Inflammation ,Kidney ,Gastroenterology ,Antibodies ,donor-specific antibodies ,Microcirculation ,microcirculation inflammation ,Risk Factors ,Internal medicine ,Complement C4b ,medicine ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,Renal Insufficiency ,Retrospective Studies ,Transplantation ,Models, Statistical ,medicine.diagnostic_test ,biology ,business.industry ,Donor specific antibodies ,Graft Survival ,Retrospective cohort study ,Middle Aged ,renal transplantation ,Kidney Transplantation ,Peptide Fragments ,Tissue Donors ,C4d ,Surgery ,Renal transplant ,Antibody-mediated rejection ,histopathology ,biology.protein ,Female ,Histopathology ,medicine.symptom ,Antibody ,business ,Immunosuppressive Agents - Abstract
In renal transplant patients with de novo donor-specific antibodies (dnDSA) we studied the value of microcirculation inflammation (MI; defined by the addition of glomerulitis (g) and peritubular capillaritis (ptc) scores) to assess long-term graft survival in a retrospective cohort study. Out of all transplant patients with standard immunological risk (n = 638), 79 (12.4%) developed dnDSA and 58/79 (73%) had an indication biopsy at or after dnDSA development. Based on the MI score on that indication biopsy patients were categorized, MI0 (n = 26), MI1 + 2 (n = 21) and MI ≥ 3 (n = 11). The MI groups did not differ significantly pretransplantation, whereas posttransplantation higher MI scores developed more anti-HLA class I + II DSA (p = 0.011), showed more TCMR (p
- Published
- 2013
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