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Your search keyword '"Heng, A. E."' showing total 10 results
Start Over Author "Heng, A. E." Journal american journal of transplantation
10 results on '"Heng, A. E."'

1. Rituximab for recurrence of primary focal segmental glomerulosclerosis after kidney transplantation: Results of a nationwide study

Author

Lanaret, Camille, Anglicheau, Dany, Audard, Vincent, Büchler, Mathias, Caillard, Sophie, Couzi, Lionel, Malvezzi, Paolo, Mesnard, Laurent, Bertrand, Dominique, Martinez, Franck, Pernin, Vincent, Ducloux, Didier, Poulain, Coralie, Thierry, Antoine, Del Bello, Arnaud, Rerolle, Jean P., Greze, Clarisse, Uro-Coste, Charlotte, Aniort, Julien, Lambert, Céline, Bouvier, Nicolas, Schvartz, Betoul, Maillard, Nicolas, Sayegh, Johnny, Oniszczuk, Julie, Morin, Marie-Pascale, Legendre, Christophe, Kamar, Nassim, Heng, Anne E., and Garrouste, Cyril

Published
2021
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2. Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study

Author

Gatault, P., Kamar, N., Büchler, M., Colosio, C., Bertrand, D., Durrbach, A., Albano, L., Rivalan, J., Le Meur, Y., Essig, M., Bouvier, N., Legendre, C., Moulin, B., Heng, A.-E., Weestel, P.-F., Sayegh, J., Charpentier, B., Rostaing, L., Thervet, E., and Lebranchu, Y.

Published
2017
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9. Effect of an Early Switch to Belatacept Among Calcineurin Inhibitor–Intolerant Graft Recipients of Kidneys From Extended‐Criteria Donors

Author

Le Meur, Y., Aulagnon, F., Bertrand, D., Heng, A. E., Lavaud, S., Caillard, S., Longuet, H., Sberro‐Soussan, R., Doucet, L., Grall, A., and Legendre, C.

Abstract

Transplant recipients receiving a kidney from an extended‐criteria donor (ECD) are exposed to calcineurin inhibitor (CNI) nephrotoxicity, as demonstrated by severe delayed graft function and/or a low GFR. Belatacept is a nonnephrotoxic drug that is indicated as an alternative to CNIs. We reported 25 cases of conversion from a CNIto belatacept due to CNIintolerance within the first 6 mo after transplantation. The mean age of the recipients was 59 years, and 24 of 25 patients received ECDkidneys. At the date of the medication switch, 12 of 25 patients displayed a calculated GFR (cGFR)<15 mL/min, six patients remained on dialysis, and the biopsies showed evidence of acute tubular damage associated with severe vascular or tubulointerstitial chronic lesions. Three patients did not recover renal function, and three patients died during the follow‐up period. Among the remaining patients, renal function improved: The cGFRwas 18.28 ± 12.3 mL/min before the medication switch compared with 34.9 ± 14.5 mL/min at 1 year after conversion to belatacept (p = 0.002). Tolerance of and compliance with belatacept were good, and only one patient experienced acute rejection. Belatacept is an effective therapy that preserves renal function in kidney transplant patients who are intolerant of CNIs. An early switch from calcineurin inhibitors (CNIs) to belatacept improves renal function in CNI‐intolerant graft recipients of kidneys from extended criteria donors.

Published
2016
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10. Kidney Transplant Recipients Carrying the CYP3A4*22Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations

Author

Pallet, N., Jannot, A.‐S., El Bahri, M., Etienne, I., Buchler, M., de Ligny, B. H., Choukroun, G., Colosio, C., Thierry, A., Vigneau, C., Moulin, B., Le Meur, Y., Heng, A.‐E., Subra, J.‐F., Legendre, C., Beaune, P., Alberti, C., Loriot, M. A., and Thervet, E.

Abstract

This study demonstrates that kidney transplant recipients who carry the CYP3A4*22allelic variant and are low expressors of the cytochrome P450 3A4 in the liver have an increased risk of tacrolimus overexposure and need doses that are 30% lower than individuals who express the cytochrome P450 3A4.

Published
2015
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