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In a double blind study in 20 patients a newly synthesized contrast agent Ph DZ 59B was found to give significantly less subjective adverse effects than a metrizoate preparation when compared at the same iodine concentration in carotid arteriography. This is in agreement with our results of earlier double blind studies in peripheral arteriography and angiocardiography.

In a series of 20 patients being routinely examined by angiocardiography or thoracic aortography as part of a preoperative evaluation for cardiac disease, a newly synthesized contrast agent Ph DZ 59B was compared with methylglucamine diatrizoate.When compared in a double blind study at the same iodine concentration, Ph DZ 59B was found to give less subjective adverse effects and also significantly less changes in heart rate and systolic blood pressure than methylglucamine diatrizoate.

A new contrast agent has been synthesized and tested in double-blind studies on 36 patients in peripheral arteriography. When compared with some other contrast media in current use at the same or near the same iodine concentration, this new agent gave angiograms of comparable quality, with significantly less subjective adverse effects in the form of pain and sensation of heat. The increase in heart rate after injection of this new agent was also less than after similar injections of the other contrast media.

Fifty-nine proven, operated cases of coarctation of the aorta in children from I month to 15 years of age have been analyzed from the findings on standard chest roentgenograms, which were correlated with those of biplane angiocardiograms.The presence of the usually reported signs in adults is apparently directly related[See Figure in the PDF file]to the development of collateral circulation, and, as a result these signs are generally absent in the young and increase in incidence with age. Rib notching, the most valuable sign other than descending aortic or left mediastinal contour deviation, was present in 49 per cent of the cases, the youngest being 4 years of age.The diagnosis of coarctation of the aorta from standard roentgenograms is very difficult in patients under 6 years of age but over that age an 85 per cent accuracy may be expected.

In a series of 60 aortographies in 47 patients with aortic aneurysm, percutaneous transfemoral catheterization using the Seldinger technique was successful in 85 per cent of the instances. Complications, such as perforation of an aneursym or dislodging of thrombotic material, did not occur.