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Start Over Author "Kirby, Miranda" Journal american journal of respiratory and critical care medicine
17 results on '"Kirby, Miranda"'

1. Physiological Characterization of Preserved Ratio Impaired Spirometry in the CanCOLD Study: Implications for Exertional Dyspnea and Exercise Intolerance

Author

Phillips, Devin B, primary, James, Matthew D., additional, Vincent, Sandra G, additional, Elbehairy, Amany F, additional, Neder, J Alberto, additional, Kirby, Miranda, additional, Ora, Josuel, additional, Day, Andrew G, additional, Tan, Wan C, additional, Bourbeau, Jean, additional, and O'Donnell, Denis E., additional

Published
2024
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2. Effects of Dupilumab on Mucus Plugging and Ventilation Defects in Patients with Moderate-to-Severe Asthma: A Randomized, Double-Blind, Placebo-Controlled Trial

Author

Svenningsen, Sarah, primary, Kjarsgaard, Melanie, additional, Haider, Ehsan, additional, Venegas, Carmen, additional, Konyer, Norman, additional, Friedlander, Yonni, additional, Nasir, Neha, additional, Boylan, Colm, additional, Kirby, Miranda, additional, and Nair, Parameswaran, additional

Published
2023
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3. Residual Volume versus FRC Computed Tomography Assessment of Functional Small Airway Disease in Smokers with and without Chronic Obstructive Pulmonary Disease

Author

Comellas, Alejandro P., primary, Newell, John D., additional, Kirby, Miranda, additional, Sieren, Jered P., additional, Peterson, Sam, additional, Hatt, Charles, additional, Galban, Craig J., additional, Kazerooni, Ella A., additional, Lynch, David A., additional, Han, MeiLan K., additional, and Hoffman, Eric A., additional

Published
2023
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5. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study

Author

Bourbeau, Jean, primary, Doiron, Dany, additional, Biswas, Sharmistha, additional, Smith, Benjamin M., additional, Benedetti, Andrea, additional, Brook, Jeffrey R., additional, Aaron, Shawn D., additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis, additional, Sin, Don D., additional, Walker, Brandie, additional, Dsilva, Liesel, additional, Nadeau, Gilbert, additional, Coats, Valérie, additional, Compton, Chris, additional, Miller, Bruce E., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, FitzGerald, J. Mark, additional, O’Donnell, Denis E., additional, Aaron, Shawn, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Mancino, Palmina, additional, Li, Pei Zhi, additional, Jensen, Dennis, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Kirby, Miranda, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonté, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, Vincent, Sandra, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2022
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6. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study

Author

Phillips, Devin B., primary, Elbehairy, Amany F., additional, James, Matthew D., additional, Vincent, Sandra G., additional, Milne, Kathryn M., additional, de-Torres, Juan P., additional, Neder, J. Alberto, additional, Kirby, Miranda, additional, Jensen, Dennis, additional, Stickland, Michael K., additional, Guenette, Jordan A., additional, Smith, Benjamin M., additional, Aaron, Shawn D., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, O’Donnell, Denis E., additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hogg, James C., additional, Hamid, Qutayba, additional, Doiron, Dany, additional, Mancino, Palmina, additional, Li, Pei-Zhi, additional, Song, Zhi, additional, Fortier, Yvan, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Duke, Jane, additional, Gershon, Andrea S., additional, Toh, Teresa, additional, Sadatsafavi, Mohsen, additional, Sin, Don, additional, Fitzgerald, J. Mark, additional, Road, Jeremy, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Cheng, Michael, additional, Fung, Cynthia, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Choi, Rena, additional, Comeau, Joe, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Walker, Brandie, additional, Dumonceaux, Curtis, additional, Hernandez, Paul, additional, Fulton, Scott, additional, Vandemheen, Kathy, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Maltais, Francois, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, and Baran, Janet, additional

Published
2022
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8. Dysanapsis and the Spirometric Response to Inhaled Bronchodilators

Author

Vameghestahbanati, Motahareh, primary, Kirby, Miranda, additional, Maltais, François, additional, Jensen, Dennis, additional, Doiron, Dany, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Smith, Benjamin M., additional, Lacasse, Yves, additional, O’Donnell, Denis, additional, Cowie, Robert, additional, Chapman, Kenneth, additional, Goldstein, Roger, additional, Marciniuk, Darcy, additional, Shawn, Aaron, additional, Benedetti, Andrea, additional, Hernandez, Paul, additional, Fitzgerald, Mark, additional, To, Teresa, additional, Perrault, Hélène, additional, Taivassalo, Tanja, additional, Sheel, William, additional, Pare, Peter, additional, and C. Hogg, James, additional

Published
2021
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10. Central Airway Tree Dysanapsis Extends to the Peripheral Airways

Author

Vameghestahbanati, Motahareh, primary, Kirby, Miranda, additional, Tanabe, Naoya, additional, Vasilescu, Dragoş M., additional, Janssens, Wim, additional, Everaerts, Stephanie, additional, Vanaudenaerde, Bart M., additional, Benedetti, Andrea, additional, Hogg, James C., additional, and Smith, Benjamin M., additional

Published
2021
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11. Pathological Comparisons of Paraseptal and Centrilobular Emphysema in Chronic Obstructive Pulmonary Disease

Author

Tanabe, Naoya, primary, Vasilescu, Dragoş M., additional, Hague, Cameron J., additional, Ikezoe, Kohei, additional, Murphy, Darra T., additional, Kirby, Miranda, additional, Stevenson, Christopher S., additional, Verleden, Stijn E., additional, Vanaudenaerde, Bart M., additional, Gayan-Ramirez, Ghislaine, additional, Janssens, Wim, additional, Coxson, Harvey O., additional, Paré, Peter D., additional, and Hogg, James C., additional

Published
2020
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13. Computed Tomography Total Airway Count Is Associated with the Number of Micro–Computed Tomography Terminal Bronchioles

Author

Kirby, Miranda, primary, Tanabe, Naoya, additional, Vasilescu, Dragoş M., additional, Cooper, Joel D., additional, McDonough, John E., additional, Verleden, Stijn E., additional, Vanaudenaerde, Bart M., additional, Sin, Don D., additional, Tan, Wan C., additional, Coxson, Harvey O., additional, and Hogg, James C., additional

Published
2020
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15. Chronic Hypoxia Accentuates Dysanaptic Lung Growth

Author

Llapur, Conrado J., primary, Martínez, Myriam R., additional, Grassino, Pedro T., additional, Stok, Ana, additional, Altieri, Héctor H., additional, Bonilla, Federico, additional, Caram, María M., additional, Krowchuk, Natasha M., additional, Kirby, Miranda, additional, Coxson, Harvey O., additional, and Tepper, Robert S., additional

Published
2016
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16. Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan.

Author

Debban CL, Ambalavanan A, Ghosh A, Li Z, Buschur KL, Ma Y, George E, Pistenmaa C, Bertoni AG, Oelsner EC, Michos ED, Moraes TJ, Jacobs DR Jr, Christenson S, Bhatt SP, Kaner RJ, Simons E, Turvey SE, Vameghestahbanati M, Engert JC, Kirby M, Bourbeau J, Tan WC, Gabriel SB, Gupta N, Woodruff PG, Subbarao P, Ortega VE, Bleecker ER, Meyers DA, Rich SS, Hoffman EA, Barr RG, Cho MH, Bossé Y, Duan Q, Manichaikul A, and Smith BM

Abstract

Rationale Dysanapsis refers to a mismatch between airway tree caliber and lung size arising early in life. Dysanapsis assessed by computed tomography (CT) is evident by early adulthood and associated with chronic obstructive pulmonary disease (COPD) risk later in life. Objective By examining the genetic factors associated with CT-assessed dysanapsis, we aimed to elucidate its molecular underpinnings and physiological significance across the lifespan. Methods We performed a genome-wide association study (GWAS) of CT-assessed dysanapsis in 11,951 adults, including individuals from two population-based and two COPD-enriched studies. We applied colocalization analysis to integrate GWAS and gene expression data from whole blood and lung. Genetic variants associated with dysanapsis were combined into a genetic risk score that was applied to examine association with lung function in children from a population-based birth cohort (n=1,278) and adults from the UK Biobank (n=369,157). Measurements and Main Results CT-assessed dysanapsis was associated with genetic variants from 21 independent signals in 19 gene regions, implicating HHIP , DSP , and NPNT as potential molecular targets based on colocalization of their expression. Higher dysanapsis genetic risk score was associated with obstructive spirometry among 5 year old children and among adults in the 5th, 6th and 7th decades of life. Conclusions CT-assessed dysanapsis is associated with variation in genes previously implicated in lung development and dysanapsis genetic risk is associated with obstructive lung function from early life through older adulthood. Dysanapsis may represent an endo-phenotype link between the genetic variations associated with lung function and COPD.

Published
2024
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