1. CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap
- Author
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Payam, Nahid, Jussi, Saukkonen, William R, Mac Kenzie, John L, Johnson, Patrick P J, Phillips, Janet, Andersen, Erin, Bliven-Sizemore, John T, Belisle, W Henry, Boom, Annie, Luetkemeyer, Thomas B, Campbell, Kathleen D, Eisenach, Richard, Hafner, Jeffrey L, Lennox, Mamodikoe, Makhene, Susan, Swindells, M Elsa, Villarino, Marc, Weiner, Constance, Benson, and William, Burman
- Subjects
Clinical Trials as Topic ,Treatment Outcome ,Antitubercular Agents ,Humans ,Tuberculosis ,Biomarkers ,CDC/NIH Workshop ,Biological Specimen Banks ,Specimen Handling - Abstract
The Centers for Disease Control and Prevention and National Institutes of Health convened a multidisciplinary meeting to discuss surrogate markers of treatment response in tuberculosis. The goals were to assess recent surrogate marker research and to provide specific recommendations for (1) the qualification and validation of biomarkers of treatment outcome; (2) the standardization of specimen and data collection for future clinical trials, including a minimum set of samples and collection time points; and (3) the creation of a specimen repository to support biomarker testing. This article summarizes these recommendations and provides a roadmap for their implementation.
- Published
- 2011