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Your search keyword '"Christopher B Cooper"' showing total 11 results
Start Over Author "Christopher B Cooper" Journal american journal of respiratory and critical care medicine
11 results on '"Christopher B Cooper"'

1. Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

Author

Russell G. Buhr, Igor Z. Barjaktarevic, P. Miguel Quibrera, Lori A. Bateman, Eugene R. Bleecker, David J. Couper, Jeffrey L. Curtis, Brett A. Dolezal, MeiLan K. Han, Nadia N. Hansel, Jerry A. Krishnan, Fernando J. Martinez, William McKleroy, Robert Paine, Stephen I. Rennard, Donald P. Tashkin, Prescott G. Woodruff, Richard E. Kanner, Christopher B. Cooper, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, R. Graham Barr, Surya P. Bhatt, Richard C. Boucher, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Gerard J. Criner, Ronald G. Crystal, Claire M. Doerschuk, Mark T. Dransfield, Brad Drummond, Christine M. Freeman, Craig Galban, Annette T. Hastie, Eric A. Hoffman, Yvonne Huang, Robert J. Kaner, Eric C. Kleerup, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Laura Paulin, Stephen P. Peters, Cheryl Pirozzi, Nirupama Putcha, Elizabeth C. Oelsner, Wanda K. O’Neal, Victor E. Ortega, Sanjeev Raman, J. Michael Wells, and Robert A. Wise

Subjects
Airway Obstruction, Cohort Studies, Pulmonary and Respiratory Medicine, Pulmonary Disease, Chronic Obstructive, Spirometry, Forced Expiratory Volume, Vital Capacity, Humans, Critical Care and Intensive Care Medicine, Asthma, Bronchodilator Agents
Published
2022
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2. Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease

Author

Siddharth S. Madapoosi, Charmion Cruickshank-Quinn, Kristopher Opron, John R. Erb-Downward, Lesa A. Begley, Gen Li, Igor Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, David J. Couper, Christopher B. Cooper, Christine M. Freeman, MeiLan K. Han, Robert J. Kaner, Wassim Labaki, Fernando J. Martinez, Victor E. Ortega, Stephen P. Peters, Robert Paine, Prescott Woodruff, Jeffrey L. Curtis, Gary B. Huffnagle, Kathleen A. Stringer, Russell P. Bowler, Charles R. Esther, Nichole Reisdorph, Yvonne J. Huang, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, Lori A. Bateman, Surya P. Bhatt, Eugene R. Bleecker, Richard C. Boucher, Stephanie A. Christenson, Gerard J. Criner, Ronald G. Crystal, Claire M. Doerschuk, Mark T. Dransfield, Brad Drummond, Craig Galban, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Richard E. Kanner, Eric C. Kleerup, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Laura Paulin, Cheryl Pirozzi, Nirupama Putcha, Elizabeth C. Oelsner, Wanda K. O’Neal, Sanjeev Raman, Stephen I. Rennard, Donald P. Tashkin, J. Michael Wells, and Robert A. Wise

Subjects
Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Published
2022
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3. Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of Chronic Obstructive Pulmonary Disease

Author

Jerry A. Krishnan, Miranda R. Jones, Richard E. Kanner, Russell P. Bowler, Eric A. Hoffman, Nirupama Putcha, Nadia N. Hansel, Laura M. Paulin, Han Woo, Trisha M. Parekh, Victor E. Ortega, Panagis Galiatsatos, Gabriela R. Oates, MeiLan K. Han, Amanda J. Gassett, R. Graham Barr, Christopher B. Cooper, Joel D. Kaufman, Stephanie A. Christenson, Sarath Raju, Kassandra Allbright, D. Belz, Emily P. Brigham, Alejandro P. Comellas, C.O. Ejike, Fernando J. Martinez, and Gerard J. Criner

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Urban Population, Pulmonary disease, Critical Care and Intensive Care Medicine, Health outcomes, Pulmonary Disease, Chronic Obstructive, Residence Characteristics, Surveys and Questionnaires, Humans, Medicine, Respiratory system, Intensive care medicine, Aged, Aged, 80 and over, COPD, Social Segregation, business.industry, Editorials, Health Status Disparities, Middle Aged, medicine.disease, United States, Health equity, Black or African American, Social Class, Female, business
Abstract

Rationale: Racial residential segregation has been associated with worse health outcomes, but the link with chronic obstructive pulmonary disease (COPD) morbidity has not been established.Objective...

Published
2021
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4. Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers

Author

Richard C. Boucher, Travis S. Henry, Wanda K. O'Neal, Russell P. Bowler, Robert Paine, Igor Barjaktarevic, Joyce D. Schroeder, MeiLan K. Han, Eugene R. Bleecker, Alejandro P. Comellas, Christopher B. Cooper, Jerry A. Krishnan, Stephen P. Peters, R. Graham Barr, Mark T. Dransfield, Annette T. Hastie, Stephanie A. Christenson, Eric A. Hoffman, Mark L. Schiebler, Prescott G. Woodruff, Claire M. Doerschuk, Brett M. Elicker, Victor E. Ortega, Gerard J. Criner, Stephen C. Lazarus, Fernando J. Martinez, David S. Gierada, David Couper, Charles E. McCulloch, Eleanor M. Dunican, John V. Fahy, M. Bradley Drummond, Nadia N. Hansel, and Wayne Anderson

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Airflow, Pulmonary disease, Computed tomography, Critical Care and Intensive Care Medicine, Airflow obstruction, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, 030212 general & internal medicine, COPD, medicine.diagnostic_test, business.industry, respiratory system, medicine.disease, Pathophysiology, respiratory tract diseases, 030228 respiratory system, Mucus plugs, Cardiology, medicine.symptom, business, circulatory and respiratory physiology
Abstract

Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain.Objectives: T...

Published
2021
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5. Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts

Author

Jason D. Keene, Sean Jacobson, Katerina Kechris, Gregory L. Kinney, Marilyn G. Foreman, Claire M. Doerschuk, Barry J. Make, Jeffrey L. Curtis, Stephen I. Rennard, R. Graham Barr, Eugene R. Bleecker, Richard E. Kanner, Eric C. Kleerup, Nadia N. Hansel, Prescott G. Woodruff, MeiLan K. Han, Robert Paine, Fernando J. Martinez, Russell P. Bowler, Wanda K. O’Neal, Neil E. Alexis, Wayne H. Anderson, Richard C. Boucher, Elizabeth E. Carretta, Stephanie A. Christenson, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Ronald G. Crystal, Mark T. Dransfield, Christine M. Freeman, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, John D. Newell, Elizabeth C. Oelsner, Nirupama Putcha, Donald P. Tashkin, Mary Beth Scholand, J. Michael Wells, and Robert A. Wise

Subjects
Pulmonary and Respiratory Medicine, Critical Care and Intensive Care Medicine
Published
2020
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6. A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography

Author

Russell P. Bowler, Christopher B. Cooper, Gerard J. Criner, Jerome I. Rotter, MeiLan K. Han, Deborah A. Meyers, Stephen P. Peters, Benjamin M. Smith, Xiuqing Guo, R. Graham Barr, Nadia N. Hansel, Prescott G. Woodruff, Stephen S. Rich, Robert Paine, Kent D. Taylor, Eric A. Hoffman, David Couper, Mark T. Dransfield, Ani Manichaikul, Fernando J. Martinez, Victor E. Ortega, Eugene R. Bleecker, Jerry A. Krishnan, Jennifer N. Nguyen, and Elizabeth C. Oelsner

Subjects
Male, spirometry, Respiratory System, Computed tomography, Critical Care and Intensive Care Medicine, Medical and Health Sciences, Gastroenterology, airway remodeling, 2.1 Biological and endogenous factors, Medicine, Aetiology, Genetic risk, Lung, Tomography, Cancer, COPD, medicine.diagnostic_test, Lung Cancer, Middle Aged, X-Ray Computed, Lung structure, emphysema, Respiratory, Biomedical Imaging, Female, Pulmonary and Respiratory Medicine, Spirometry, Chronic Obstructive, medicine.medical_specialty, Chronic Obstructive Pulmonary Disease, Pulmonary disease, Risk Assessment, Pulmonary Disease, Clinical Research, Internal medicine, Tobacco, Genetic variation, Genetics, Humans, Genetic Predisposition to Disease, Lung cancer, Aged, Tobacco Smoke and Health, business.industry, Prevention, medicine.disease, United States, respiratory tract diseases, Good Health and Well Being, business
Abstract

Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in lung structure remains unknown.Objectives: To characterize associations between a genetic risk score (GRS) associated with COPD susceptibility and lung structure on computed tomography (CT).Methods: We analyzed data from MESA Lung (Multi-Ethnic Study of Atherosclerosis Lung Study), a U.S. general population-based cohort, and SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study). A weighted GRS was calculated from 83 SNPs that were previously associated with lung function. Lung density, spatially matched airway dimensions, and airway counts were assessed on full-lung CT. Generalized linear models were adjusted for age, age squared, sex, height, principal components of genetic ancestry, smoking status, pack-years, CT model, milliamperes, and total lung volume.Measurements and Main Results: MESA Lung and SPIROMICS contributed 2,517 and 2,339 participants, respectively. Higher GRS was associated with lower lung function and increased COPD risk, as well as lower lung density, smaller airway lumens, and fewer small airways, without effect modification by smoking. Adjustment for CT lung structure, particularly small airway measures, attenuated associations between the GRS and FEV1/FVC by 100% and 60% in MESA and SPIROMICS, respectively. Lung structure (P 0.10), improved discrimination of moderate-to-severe COPD cases relative to clinical factors alone.Conclusions: A GRS associated with COPD susceptibility was associated with CT lung structure. Lung structure may be an important mediator of heritability and determinant of personalized COPD risk.

Published
2019
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7. Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease

Author

Mehmet Kesimer, Benjamin M. Smith, Agathe Ceppe, Amina A. Ford, Wayne H. Anderson, R. Graham Barr, Wanda K. O’Neal, Richard C. Boucher, Prescott G. Woodruff, MeiLan K. Han, Eric A. Hoffman, Fernando Martinez, Jeffrey L. Curtis, Robert Paine, Christopher B. Cooper, and Eugene R. Bleecker

Subjects
Pulmonary and Respiratory Medicine, Spirometry, Pathology, medicine.medical_specialty, Pulmonary disease, Critical Care and Intensive Care Medicine, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Text mining, X ray computed, Correspondence, medicine, Humans, 030212 general & internal medicine, Lung, medicine.diagnostic_test, business.industry, Mucin, Mucins, Airway Obstruction, 030228 respiratory system, business, Tomography, X-Ray Computed, Airway closure
Published
2018

8. The Significance of Eosinophilic Inflammation in Chronic Obstructive Pulmonary Disease

Author

Guy Brusselle, Ian D. Pavord, Christopher B. Cooper, and Steven Pascoe

Subjects
Pulmonary and Respiratory Medicine, PREDICTOR, COPD, business.industry, Pulmonary disease, Critical Care and Intensive Care Medicine, medicine.disease, EXACERBATIONS, 03 medical and health sciences, FLUTICASONE, 0302 clinical medicine, 030228 respiratory system, Eosinophilic inflammation, CUTOFF VALUE, BLOOD EOSINOPHILIA, Immunology, Medicine and Health Sciences, medicine, 030212 general & internal medicine, business, Fluticasone, medicine.drug
Published
2018
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9. Do Holes in the Lungs Beget Holes in the Bones?

Author

Christopher B. Cooper

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Bone density, business.industry, Incidence (epidemiology), Osteoporosis, Critical Care and Intensive Care Medicine, medicine.disease, Causality, Comorbidity, Severity of illness, Medicine, Risk assessment, business
Published
2011
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10. Global Initiative on Obstructive Lung Disease Revised. What Constitutes a Guideline?

Author

Christopher B. Cooper and Klaus F. Rabe

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Internationality, business.industry, Guidelines as Topic, Guideline, Critical Care and Intensive Care Medicine, medicine.disease, Obstructive lung disease, Pulmonary Disease, Chronic Obstructive, Humans, Medicine, business, Intensive care medicine, Societies, Medical
Published
2013
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11. Physiologic benefits of exercise training in rehabilitation of patients with severe chronic obstructive pulmonary disease

Author

Christopher B. Cooper, Mary R. Burns, Richard Casaburi, Eve Carithers, Robert S. Y. Chang, and Janos Porszasz

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Respiratory rate, Physical exercise, Critical Care and Intensive Care Medicine, Oxygen Consumption, Capnography, Heart Rate, Internal medicine, Heart rate, medicine, Humans, Lactic Acid, Lung Diseases, Obstructive, Tidal volume, Aged, COPD, business.industry, Pulmonary Gas Exchange, Training effect, Middle Aged, medicine.disease, Exercise Therapy, Breathing, Cardiology, Exercise intensity, Physical therapy, Exercise Test, Respiratory Mechanics, Female, business
Abstract

We determined the effect on exercise tolerance and physiological exercise responses of rigorous rehabilitative exercise training in chronic obstructive pulmonary disease (COPD). Fifteen men and 10 women (mean age, 68 +/- 6 yr; FEV1, 0.93 +/- 0.27 L) participated in a rehabilitation program with an exercise component of three per week 45-min sessions of cycle ergometer training for 6 wk with exercise intensity kept near maximal targets. Before and after rehabilitation, patients performed an incremental test and a constant work rate (CWR) test at 80% of the peak work rate in the preprogram incremental test. Ventilation (V(E)) and gas exchange were measured breath by breath; arterialized venous blood was analyzed for blood gas determinations and lactate. Rehabilitation yielded an average increase in peak work rate in the incremental test of 36% (p < 0.001), and in the duration of the CWR test of 77% (p < 0.001). In the CWR test, the kinetics of O2 uptake, CO2 output, V(E), and heart rate were markedly slower than those of healthy subjects. After training, mean response time decrease averaged 17, 22, 34, and 29%, respectively (p < 0.02), evidence of a physiologic training effect. Further, for identical CWR tasks, V(E) was 10% lower (p < 0.02) after training, attributable to altered breathing pattern: tidal volume increased by 8% and respiratory rate decreased by 19%, yielding lower V(D) /V(T) (0.46 versus 0.53 p < 0.005). Rigorous exercise training for patients with severe COPD yields more efficient exercise breathing pattern and lower V(E); this is associated with improved exercise tolerance.

Published
1997

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