1. Analysis of the therapeutic effects of hysteroscopic polypectomy with and without doxycycline treatment on chronic endometritis with endometrial polyps
- Author
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Ryo Tsutsumi, Hiroshi Motoyama, Rikikazu Sugiyama, Satoru Takamizawa, Yasushi Kuribayashi, Koji Nakagawa, Rie Sugiyama, and Keiji Kuroda
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Pregnancy Rate ,medicine.drug_class ,medicine.medical_treatment ,Immunology ,Antibiotics ,Hysteroscopy ,Gastroenterology ,03 medical and health sciences ,Endometrium ,0302 clinical medicine ,Polyps ,Pregnancy ,Internal medicine ,medicine ,Endometrial Polyp ,Immunology and Allergy ,Humans ,Doxycycline ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Therapeutic effect ,Obstetrics and Gynecology ,medicine.disease ,Polypectomy ,Anti-Bacterial Agents ,030104 developmental biology ,Cross-Sectional Studies ,Reproductive Medicine ,Chronic Disease ,Female ,Syndecan-1 ,business ,Chronic Endometritis ,Endometritis ,Infertility, Female ,medicine.drug - Abstract
PROBLEM We aimed to compare the therapeutic effects of hysteroscopic polypectomy with and without doxycycline treatment on chronic endometritis (CE) with endometrial polyps. METHOD OF STUDY DESIGN: A cross-sectional study was conducted on 267 infertile patients, of whom 243 were recruited, who underwent hysteroscopic polypectomy between March 2019 and March 2020. During surgery, the endometrial specimens for the immunohistochemistry analysis of the plasma cell marker CD138 and for the intrauterine bacterial culture were obtained to diagnose CE, and the prevalence of CE was analyzed. Of the 222 women who were diagnosed with CE after polypectomy, we treated 62 women with doxycycline (antibiotic group) and did not provide antibiotics in 160 women (non-antibiotic group). RESULTS Most of the infertile patients with endometrial polyps had CE (92.6%). The recovery rate from CE by hysteroscopic polypectomy was significantly higher in the non-antibiotic group than in the antibiotic group (88.8% and 58.1%, respectively, p
- Published
- 2020