Search

Your search keyword '"Ströhle, A"' showing total 28 results
Start Over Author "Ströhle, A" Journal american journal of psychiatry
28 results on '"Ströhle, A"'

1. Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group

Author

Hilbert, Kevin, primary, Boeken, Ole Jonas, additional, Langhammer, Till, additional, Groenewold, Nynke A., additional, Bas-Hoogendam, Janna Marie, additional, Aghajani, Moji, additional, Zugman, André, additional, Åhs, Fredrik, additional, Arolt, Volker, additional, Beesdo-Baum, Katja, additional, Björkstrand, Johannes, additional, Blackford, Jennifer U., additional, Blanco-Hinojo, Laura, additional, Böhnlein, Joscha, additional, Bülow, Robin, additional, Cano, Marta, additional, Cardoner, Narcis, additional, Caseras, Xavier, additional, Dannlowski, Udo, additional, Domschke, Katharina, additional, Fehm, Lydia, additional, Feola, Brandee, additional, Fredrikson, Mats, additional, Goossens, Liesbet, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gur, Raquel E., additional, Hamm, Alfons O., additional, Harrewijn, Anita, additional, Heinig, Ingmar, additional, Herrmann, Martin J., additional, Hofmann, David, additional, Jackowski, Andrea P., additional, Jansen, Andreas, additional, Kaczkurkin, Antonia N., additional, Kindt, Merel, additional, Kingsley, Ellen N., additional, Kircher, Tilo, additional, Klahn, Anna L., additional, Koelkebeck, Katja, additional, Krug, Axel, additional, Kugel, Harald, additional, Larsen, Bart, additional, Leehr, Elisabeth J., additional, Leonhardt, Lieselotte, additional, Lotze, Martin, additional, Margraf, Jürgen, additional, Michałowski, Jarosław, additional, Muehlhan, Markus, additional, Nenadić, Igor, additional, Pan, Pedro M., additional, Pauli, Paul, additional, Peñate, Wenceslao, additional, Pittig, Andre, additional, Plag, Jens, additional, Pujol, Jesus, additional, Richter, Jan, additional, Rivero, Francisco L., additional, Salum, Giovanni A., additional, Satterthwaite, Theodore D., additional, Schäfer, Axel, additional, Schäfer, Judith, additional, Schienle, Anne, additional, Schneider, Silvia, additional, Schrammen, Elisabeth, additional, Schruers, Koen, additional, Schulz, Stefan M., additional, Seidl, Esther, additional, Stark, Rudolf M., additional, Stein, Frederike, additional, Straube, Benjamin, additional, Straube, Thomas, additional, Ströhle, Andreas, additional, Suchan, Boris, additional, Thomopoulos, Sophia I., additional, Ventura-Bort, Carlos, additional, Visser, Renee, additional, Völzke, Henry, additional, Wabnegger, Albert, additional, Wannemüller, André, additional, Wendt, Julia, additional, Wiemer, Julian, additional, Wittchen, Hans-Ulrich, additional, Wittfeld, Katharina, additional, Wright, Barry, additional, Yang, Yunbo, additional, Zilverstand, Anna, additional, Zwanzger, Peter, additional, Veltman, Dick J., additional, Winkler, Anderson M., additional, Pine, Daniel S., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Stein, Dan J., additional, Van der Wee, Nic J.A., additional, and Lueken, Ulrike, additional

Published
2024
Full Text
View/download PDF

2. Effect of CBT on Biased Semantic Network in Panic Disorder: A Multicenter fMRI Study Using Semantic Priming

Author

Jan Richter, Martin J. Herrmann, Jürgen Deckert, Benjamin Straube, Tilo Kircher, Alfons O. Hamm, Ulrike Lueken, André Wittmann, Hans-Ulrich Wittchen, Martin Lotze, Carsten Konrad, Andreas Ströhle, Bettina Pfleiderer, Volker Arolt, Yunbo Yang, and Thomas Lang

Subjects
Adult, Male, medicine.medical_treatment, behavioral disciplines and activities, Semantic network, Young Adult, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Humans, Anterior cingulate cortex, Cognitive Behavioral Therapy, Panic disorder, Brain, medicine.disease, Magnetic Resonance Imaging, 030227 psychiatry, Cognitive behavioral therapy, Psychiatry and Mental health, Treatment Outcome, medicine.anatomical_structure, Panic Disorder, Female, Nerve Net, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

Cognitive-behavioral therapy (CBT) has been hypothesized to act by reducing the pathologically enhanced semantic, anxiety-related associations of patients with panic disorder. This study investigated the effects of CBT on the behavioral and neural correlates of the panic-related semantic network in patients with panic disorder.An automatic semantic priming paradigm specifically tailored for panic disorder, in which panic symptoms (e.g., "dizziness") were primed by panic triggers (e.g., "elevator") compared with neutral words (e.g., "bottle"), was performed during functional MRI scanning with 118 patients with panic disorder (compared with 150 healthy control subjects) before and 42 patients (compared with 52 healthy control subjects) after an exposure-based CBT. Neural correlates were investigated by comparing 103 pairs of matched patients and control subjects at the baseline (for patients) or T1 (for control subjects) assessment and 39 pairs at the posttreatment or T2 assessment.At baseline or T1, patients rated panic-trigger/panic-symptom word pairs with higher relatedness and higher negative valence compared with healthy control subjects. Patients made faster lexical decisions to the panic-symptom words when they were preceded by panic-trigger words. This panic-priming effect in patients (compared with control subjects) was reflected in suppressed neural activation in the left and right temporal cortices and insulae and enhanced activation in the posterior and anterior cingulate cortices. After CBT, significant clinical improvements in the patient group were observed along with a reduction in relatedness and negative valence rating and attenuation of neural activation in the anterior cingulate cortex for processing of panic-trigger/panic-symptom word pairs.The findings support a biased semantic network in panic disorder, which is normalized after CBT. Attenuation of anterior cingulate cortex activation for processing of panic-related associations provides a potential mechanism for future therapeutic interventions.

Published
2020

3. Effect of CBT on Biased Semantic Network in Panic Disorder: A Multicenter fMRI Study Using Semantic Priming

Author

Yang, Yunbo, primary, Lueken, Ulrike, additional, Richter, Jan, additional, Hamm, Alfons, additional, Wittmann, André, additional, Konrad, Carsten, additional, Ströhle, Andreas, additional, Pfleiderer, Bettina, additional, Herrmann, Martin J., additional, Lang, Thomas, additional, Lotze, Martin, additional, Deckert, Jürgen, additional, Arolt, Volker, additional, Wittchen, Hans-Ulrich, additional, Straube, Benjamin, additional, and Kircher, Tilo, additional

Published
2020
Full Text
View/download PDF

4. GABAAReceptor-Modulating Neuroactive Steroid Composition in Patients With Panic Disorder Before and During Paroxetine Treatment

Author

Augusto Pasini, Elena Romeo, Florian Holsboer, Rainer Rupprecht, Alexander Yassouridis, Flavia di Michele, and Andreas Ströhle

Subjects
Adult, Male, medicine.medical_specialty, Neuroactive steroid, Pregnanolone, Internal medicine, medicine, Humans, GABA-A Receptor Antagonists, Agoraphobia, GABAA receptor, Panic disorder, Panic, Stereoisomerism, Middle Aged, Receptors, GABA-A, medicine.disease, Paroxetine, Psychiatry and Mental health, Treatment Outcome, Endocrinology, Panic Disorder, Anxiety, Female, medicine.symptom, Psychology, Reuptake inhibitor, Anxiety disorder, Follow-Up Studies, medicine.drug
Abstract

Previous studies have shown that neuroactive steroids modulate anxiety and stress reactivity. However, no data on the possible role of these gamma-aminobutyric acid(A) (GABA(A)) receptor-modulating neuroactive steroids in patients with anxiety disorders are available.The concentrations of 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP), 3alpha,5beta-THP, 3beta,5alpha-THP, and their precursors were studied in the plasma of 10 patients with panic disorder and 10 matched healthy comparison subjects. In addition, the effects of paroxetine treatment on neuroactive steroid concentrations were studied in the panic disorder patients over a 24-week period.Unexpectedly, patients with panic disorder had significantly greater concentrations of the positive allosteric modulators 3alpha,5alpha-THP and 3alpha,5beta-THP and significantly lower concentrations of 3beta,5alpha-THP (a functional antagonist for GABA(A) agonistic steroids), which might result in greater GABA(A) receptor-mediated neuronal activity. Paroxetine treatment did not affect neuroactive steroid concentrations, which were highly stable over 24 weeks.Differences in neuroactive steroid composition in patients with panic disorder were the opposite of those seen in patients with major depression and may reflect counterregulative mechanisms against the occurrence of spontaneous panic attacks.

Published
2002

5. Anxiolytic Activity of Atrial Natriuretic Peptide in Patients With Panic Disorder

Author

Florian Holsboer, Michael Kellner, Andreas Ströhle, and Klaus Wiedemann

Subjects
Adult, Male, medicine.medical_specialty, medicine.drug_class, Placebo, behavioral disciplines and activities, Anxiolytic, Tetragastrin, Placebos, Double-Blind Method, Atrial natriuretic peptide, Internal medicine, mental disorders, medicine, Humans, Cholecystokinin, business.industry, Panic disorder, Panic, medicine.disease, humanities, Psychiatry and Mental health, Endocrinology, Anti-Anxiety Agents, cardiovascular system, Cardiology, Panic Disorder, Female, medicine.symptom, Atrial natriuretic peptide receptor, business, Receptors, Atrial Natriuretic Factor, Atrial Natriuretic Factor, Anxiety disorder
Abstract

Preclinical evidence exists for the anxiolytic activity of atrial natriuretic peptide, which is released during lactate-induced panic attacks. Atrial natriuretic peptide receptor modulation may have antipanic activity in patients with panic disorder.The effects of 150 microg of atrial natriuretic peptide and placebo on panic attacks induced by cholecystokinin tetrapeptide (CCK-4) (25 microg) were studied in 10 panic disorder patients. The panicogenic activity of CCK-4 was measured with the Acute Panic Inventory.Panic attacks occurred in seven patients in the placebo condition and in two patients in the atrial natriuretic peptide condition. CCK-4 administration was accompanied by a significant increase in Acute Panic Inventory scores. Pretreatment with atrial natriuretic peptide resulted in significantly lower Acute Panic Inventory scores than pretreatment with placebo.The results support the antipanic activity of atrial natriuretic peptide. Nonpeptidergic atrial natriuretic peptide receptor ligands may be ultimately used to treat anxiety disorders.

Published
2001

6. Effect of Flumazenil in Lactate-Sensitive Patients With Panic Disorder

Author

Florian Holsboer, Klaus Wiedemann, Michael Kellner, Alexander Yassouridis, and Andreas Ströhle

Subjects
Adult, Flumazenil, Male, medicine.medical_specialty, Hydrocortisone, Provocation test, Sodium Chloride, behavioral disciplines and activities, Sodium Lactate, chemistry.chemical_compound, Adrenocorticotropic Hormone, Double-Blind Method, Heart Rate, Internal medicine, mental disorders, Heart rate, medicine, Sodium lactate, Humans, Infusions, Intravenous, business.industry, Panic disorder, Antagonist, Panic, Receptors, GABA-A, medicine.disease, Psychiatry and Mental health, Endocrinology, chemistry, Anesthesia, Panic Disorder, Female, medicine.symptom, business, Anxiety disorder, medicine.drug
Abstract

OBJECTIVE: Flumazenil is a benzodiazepine receptor antagonist that has been reported to provoke panic attacks in patients with panic disorder. This study was undertaken to compare the effects of flumazenil and sodium lactate, the most widely studied panic provocation agent. METHOD: Ten patients with panic disorder were given infusions of saline, sodium lactate, and flumazenil in randomized order. Panic attacks, psychopathological changes, heart rate, and cortisol and ACTH secretion were recorded. RESULTS: Eight of the 10 patients experienced a panic attack after sodium lactate, but none did after flumazenil or saline. Cortisol and ACTH secretion were not enhanced by any of the treatments. Sodium lactate increased heart rate, whereas flumazenil had the opposite effect. CONCLUSIONS: These findings do not lend support to the view that the benzodiazepine receptors of lactate-susceptible patients with panic disorder are hypersensitive and that flumazenil can therefore act as an inverse agonist.

Published
1998

8. Dietrich Bonhoeffer (1906–1945)

Author

Jana Wrase, Christof Gestrich, Henry Malach, Andreas Heinz, and Andreas Ströhle

Subjects
Psychiatry and Mental health, History, Germany, Humans, Theology, History, 20th Century, Christianity
Published
2008

10. Dr. Bauer and Colleagues Reply

Author

Michael Bauer, Bruno Müller-Oerlinghausen, Tom Bschor, Dieter Kunz, Anne Berghöfer, and Andreas Ströhle

Subjects
Psychiatry and Mental health
Published
2001

15. Dr. Ströhle and Colleagues Reply

Author

STRÖHLE, ANDREAS, primary, ROMEO, ELENA, additional, di MICHELE, FLAVIA, additional, PASINI, AUGUSTO, additional, YASSOURIDIS, ALEXANDER, additional, HOLSBOER, FLORIAN, additional, and RUPPRECHT, RAINER, additional

Published
2003
Full Text
View/download PDF

18. Dr. Bauer and Colleagues Reply

Author

BAUER, MICHAEL, primary, BSCHOR, TOM, additional, KUNZ, DIETER, additional, BERGHÖFER, ANNE, additional, STRÖHLE, ANDREAS, additional, and MÜLLER-OERLINGHAUSEN, BRUNO, additional

Published
2001
Full Text
View/download PDF

20. Dr. Ströhle and Colleagues Reply

Author

Andreas Ströhle, Elena Romeo, Alexander Yassouridis, Augusto Pasini, Flavia di Michele, Florian Holsboer, and Rainer Rupprecht

Subjects
Psychiatry and Mental health
Published
2003

22. Paroxetine for Depersonalization Associated With Multiple Sclerosis

Author

Andreas Ströhle, Tania Kümpfel, and Annette Sonntag

Subjects
Psychiatry and Mental health, Text mining, business.industry, Multiple sclerosis, Depersonalization, medicine, medicine.symptom, business, medicine.disease, Paroxetine, medicine.drug, Clinical psychology
Published
2000

25. Risk taking and the adolescent reward system: a potential common link to substance abuse.

Author

Schneider S, Peters J, Bromberg U, Brassen S, Miedl SF, Banaschewski T, Barker GJ, Conrod P, Flor H, Garavan H, Heinz A, Ittermann B, Lathrop M, Loth E, Mann K, Martinot JL, Nees F, Paus T, Rietschel M, Robbins TW, Smolka MN, Spanagel R, Ströhle A, Struve M, Schumann G, and Büchel C

Subjects
Adolescent, Anticipation, Psychological physiology, Case-Control Studies, Female, Functional Neuroimaging, Gambling physiopathology, Gambling psychology, Humans, Magnetic Resonance Imaging, Male, Psychology, Adolescent, Substance-Related Disorders physiopathology, Basal Ganglia physiology, Reward, Risk-Taking, Substance-Related Disorders psychology
Abstract

Objective: Increased risk-taking behavior has been associated with addiction, a disorder also linked to abnormalities in reward processing. Specifically, an attenuated response of reward-related areas (e.g., the ventral striatum) to nondrug reward cues has been reported in addiction. One unanswered question is whether risk-taking preference is associated with striatal reward processing in the absence of substance abuse., Method: Functional and structural MRI was performed in 266 healthy young adolescents and in 31 adolescents reporting potentially problematic substance use. Activation during reward anticipation (using the monetary incentive delay task) and to gray matter density were measured. Risk-taking bias was assessed by the Cambridge Gamble Task., Results: With increasing risk-taking bias, the ventral striatum showed decreased activation bilaterally during reward anticipation. Voxel-based morphometry showed that greater risk-taking bias was also associated with and partially mediated by lower gray matter density in the same structure. The decreased activation was also observed when participants with virtually any substance use were excluded. The group with potentially problematic substance use showed greater risk taking as well as lower striatal activation relative to matched comparison subjects from the main sample., Conclusions: Risk taking and functional and structural properties of the reward system in adolescents are strongly linked prior to a possible onset of substance abuse, emphasizing their potential role in the predisposition to drug abuse.

Published
2012
Full Text
View/download PDF

26. Lower ventral striatal activation during reward anticipation in adolescent smokers.

Author

Peters J, Bromberg U, Schneider S, Brassen S, Menz M, Banaschewski T, Conrod PJ, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Smolka M, Ströhle A, Struve M, Loth E, Schumann G, and Büchel C

Subjects
Adolescent, Basal Ganglia physiology, Case-Control Studies, Exploratory Behavior, Female, Humans, Magnetic Resonance Imaging, Male, Marijuana Abuse physiopathology, Marijuana Abuse psychology, Neuropsychological Tests, Personality Assessment, Smoking psychology, Anticipation, Psychological physiology, Basal Ganglia physiopathology, Reward, Smoking physiopathology
Abstract

Objective: Adolescents are particularly vulnerable to addiction, and in the case of smoking, this often leads to long-lasting nicotine dependence. The authors investigated a possible neural mechanism underlying this vulnerability., Method: Functional MRI was performed during reward anticipation in 43 adolescent smokers and 43 subjects matched on age, gender, and IQ. The authors also assessed group differences in novelty seeking, impulsivity, and reward delay discounting., Results: In relation to the comparison subjects, the adolescent smokers showed greater reward delay discounting and higher scores for novelty seeking. Neural responses in the ventral striatum during reward anticipation were significantly lower in the smokers than in the comparison subjects, and in the smokers this response was correlated with smoking frequency. Notably, the lower response to reward anticipation in the ventral striatum was also observed in smokers (N=14) who had smoked on fewer than 10 occasions., Conclusions: The present findings suggest that a lower response to reward anticipation in the ventral striatum may be a vulnerability factor for the development of early nicotine use.

Published
2011
Full Text
View/download PDF

27. Gamma-hydroxybutyrate dependence with social phobia.

Author

Trendelenburg G, Heinz A, and Ströhle A

Subjects
Adjuvants, Anesthesia administration & dosage, Adult, Cognitive Behavioral Therapy methods, Humans, Male, Paroxetine therapeutic use, Phobic Disorders therapy, Psychomotor Agitation drug therapy, Psychomotor Agitation etiology, Selective Serotonin Reuptake Inhibitors therapeutic use, Sleep Initiation and Maintenance Disorders chemically induced, Sleep Initiation and Maintenance Disorders drug therapy, Sodium Oxybate administration & dosage, Adjuvants, Anesthesia adverse effects, Phobic Disorders drug therapy, Sodium Oxybate adverse effects
Published
2004
Full Text
View/download PDF

28. GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment.

Author

Ströhle A, Romeo E, di Michele F, Pasini A, Yassouridis A, Holsboer F, and Rupprecht R

Subjects
Adult, Agoraphobia blood, Agoraphobia psychology, Female, Follow-Up Studies, GABA-A Receptor Antagonists, Humans, Male, Middle Aged, Panic Disorder blood, Panic Disorder psychology, Paroxetine adverse effects, Receptors, GABA-A physiology, Stereoisomerism, Treatment Outcome, Agoraphobia drug therapy, Panic Disorder drug therapy, Paroxetine therapeutic use, Pregnanolone blood, Receptors, GABA-A drug effects
Abstract

Objective: Previous studies have shown that neuroactive steroids modulate anxiety and stress reactivity. However, no data on the possible role of these gamma-aminobutyric acid(A) (GABA(A)) receptor-modulating neuroactive steroids in patients with anxiety disorders are available., Method: The concentrations of 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP), 3alpha,5beta-THP, 3beta,5alpha-THP, and their precursors were studied in the plasma of 10 patients with panic disorder and 10 matched healthy comparison subjects. In addition, the effects of paroxetine treatment on neuroactive steroid concentrations were studied in the panic disorder patients over a 24-week period., Results: Unexpectedly, patients with panic disorder had significantly greater concentrations of the positive allosteric modulators 3alpha,5alpha-THP and 3alpha,5beta-THP and significantly lower concentrations of 3beta,5alpha-THP (a functional antagonist for GABA(A) agonistic steroids), which might result in greater GABA(A) receptor-mediated neuronal activity. Paroxetine treatment did not affect neuroactive steroid concentrations, which were highly stable over 24 weeks., Conclusions: Differences in neuroactive steroid composition in patients with panic disorder were the opposite of those seen in patients with major depression and may reflect counterregulative mechanisms against the occurrence of spontaneous panic attacks.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results