1. A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke
- Author
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Tiffany Low, Jingjie Zhang, Emmanuel Guedj, Ansgar Buettner, Julia Hoeng, Kyeonghee Monica Lee, Tom Lee, Blaine Phillips, Alain Sewer, Patrice Leroy, Yang Xiang, Bjoern Titz, Walter K. Schlage, Arkadiusz K. Kuczaj, Ee Tsin Wong, Justyna Szostak, Patrick Vanscheeuwijck, Nikolai V. Ivanov, Florian Martin, Sin Kei Wong, Ashutosh Kumar, Karsta Luettich, and Manuel C. Peitsch
- Subjects
Systems toxicology ,Inhalation ,Physiology ,business.industry ,Urinary system ,Inflammation ,medicine.disease_cause ,complex mixtures ,law.invention ,Proinflammatory cytokine ,law ,Physiology (medical) ,Immunology ,medicine ,Cigarette smoke ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Electronic cigarette ,Oxidative stress - Abstract
Analysis of key urinary oxidative stress markers and proinflammatory cytokines showed an absence of oxidative stress and inflammation in the animals exposed to E-vapor aerosols. Conversely, animals exposed to conventional cigarette smoke had high urinary levels of these markers. When compared with conventional cigarette smoke, E-vapor aerosols induced smaller atherosclerotic plaque surface area and volume. Systolic and diastolic cardiac function, as well as endothelial function, were further significantly less affected by electronic cigarette aerosols than conventional cigarette smoke. Molecular analysis demonstrated that E-vapor aerosols induce significantly smaller transcriptomic dysregulation in the heart and aorta compared with conventional cigarette smoke.
- Published
- 2020