Search

Investigates the conditions antecedent to advanced morbidity in sleep-deprived rats by determining the time course and distribution of live microorganisms in body tissues that are normally sterile. Mechanisms by which sleep deprivation appears to adversely affect health; Bacterial translocation and pathogenic sequelae.

Discusses the use of unanesthetized rats to survey the firing patterns of neurons in various regions of rat basal forebrain (BF) and hypothalamus during spontaneous sleep and waking. Evaluation of the potential neuronal mechanisms for the somnogenic effects of lipopolysaccharide administration; Changes in neuronal activity in regions of BF and hypothalamus.

Examines whether slow-wave activity in the electroencephalogram reflects the depth or intensity of sleep, using an auditory stimuli of 72-90 dB, to control or sleep-deprived rabbits. Influence of prior waking on arousability; Behavioral responses and the latency to return to sleep as dependent measures of arousability from sleep.

Evaluates the influence of light on sleep patterns after microbial challenge. Subjects and experimental design; Electrophysiological recordings; Fungal inocula and blood analysis; Statistical analysis.

Compares acute phase responses induced in rabbits by microbial lipopolysaccharide and double-stranded RNA. Systemic and central reactions from infection or injury; Luecocyte number; Body temperature; Antiviral activity; Ceruloplasmin; Fibrinogen.