1. General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system.
- Author
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Castrop, Hayo, Klar, Jürgen, Wagner, Charlotte, Höcherl, Klaus, and Kurtz, Armin
- Subjects
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RENIN-angiotensin system , *CYCLOOXYGENASES , *KIDNEY cortex , *ANGIOTENSIN converting enzyme - Abstract
Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed a high-, normal-, or low-salt diet or were chronically infused with furosemide (60 mg·kg[sup -1]· day[sup -1]) or the left renal artery was clipped, and the animals were treated in addition to or without the angiotensin-convetting enzyme inhibitor ramipril (10 mg·kg[sup -1]·day[sup -1]). A high-salt diet reduced expression of COX-2, whereas a lowsalt diet, furosemide infusion, and renal artery stenosis stimulated COX-2 expression. Additional angiotensin-converting enzyme inhibition led to further increases in renocortical COX-2 expression by 62, 136, 300, 50, and 70% for a high-, normal-, and low-salt diet, furosemide infusion, and renal artery stenosis, respectively. Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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