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Investigates the effect of central administration of angiotensin II on efferent renal sympathetic nerve activity. Question of whether this effect is independent of both arterial and low-pressure baroreceptors; Indication that this effect of angiotensin is mediated by central angiotensin II receptors.

Identifies the contributions of cyclooxygenase (COX) and lipoxygenase (LOX) on the expression of the renal vasoconstrictor action of angiotensin (ANG) II. Comparison of the eicosanoid pathways in the endothelin-1 renal vascular response to those involved in the vascular responses to ANG II.

Evaluates the contribution of angiotensin (ANG) II to thirst and sodium appetite of sheep. Role of central ANG II receptors in thirst caused by an increase in central or peripheral osmolality; Role of ANG receptors in mediating thirst caused by intracerebroventricular infusion of ANG II.

Determines whether a specific substance P antagonist could block the actions of angiotensin (ANG) II exogenously administered into the nucleus of the solitary tract (NTS). Hypotension and bradycardia as the only effects blocked by the antagonist; Indication that substance P may mediate the cardiovascular effects of ANG II in the NTS.

Investigates the relationships between angiotensins and catecholamine release from the chromaffin tissue of rainbow trout. Evidence that angiotensins can elicit catecholamine release; Method in which angiotensins effects this release.

Presents a study on renal, hormonal and cardiovascular responses to chronic angiotensin I infusion in the ovine fetus. Fetal urine composition before and after infusion of angiotensin I or saline; Composition of amniotic and allantoic fluids post infusion of angiotensin I or saline; Fetal plasma levels of aldosterone and cortisol.

Determines the contribution of endogenous brain stem angiotensin to renal sympathetic reflexes in conscious rabbits. Effect of hypoxia on baroreflex curves; Effects of Losartan or Ringer on the baroreflex curves; Effect of Losartan or Ringer on baroreflex curves during hypoxia. Effect of Losartan or Ringer on baroreflex curves during hypoxia plus carbon dioxide.

Examines whether endogenous angiotensin II (ANG II) influences baroreflex control of heart rate (HR) and renal sympathetic nerve activity (RSNA) early in life and whether these actions are mediated by angiotensin AT1 or AT2 receptors. Exogenous ANG II in mediating baroreflex responses of HR and RSNA; Role of AT1 and AT2 receptors in regulating responses.

Investigates the effects of afferent renal nerves (ARN) stimulation on subfornical organ (SFO) neurons that responded to intracarotid infusion of angiotensin II. Indication on the possible role of ARN in body fluid balance and circulatory regulation; Influence on the activity of hypothalamic nuclei that contain neurosecretory neurons.

Determines whether enhanced preglomerular response to angiotensin II during intrarenal nitric oxide synthesis inhibition occurs through voltage-gated calcium channels in dogs. Examination of renal segmental vascular resistance responses to angiotensin II in the presence or absence of intrarenal voltage-gated calcium channel blockade.

Investigates functional renal responses to acetylcholine or angiotensin II infusion in anesthetized rabbits after a control diet. Control clearance periods; Increases in nitrate/nitrite excretion; Serum cholesterol and triglycerides in control and cholesterol-fed rabbits.

Tests whether angiotensin II (ANG II) affects cardiac performance via neurons in the intrathoracic cardiac ganglia. Exclusion of possible vascular regulatory effects of ANG II; Ventricular inotropic effects elicited by ANG II; Amplitude of Cai transients; Pharmacological agents used in the study.

Examines the hypothesis that renal bradykinin production during sodium depletion is mediated by the renin-angiotensin system. Use of the in vivo renal microdialysis technique in determining renal interstitial fluid; Changes in renal excretory and hemodynamic function; Sodium and fluid balance.

Tests whether vasoactive intestinal peptide (VIP) dilates resistance arterioles in the in situ systemic circulation and whether inhibitors of neutral endopeptidase and angiotensin I-converting enzyme potentiate the response. Effects of a mixture of proteinase inhibitors on VIP-induced vasodilation; Intravital microscopy results.

Assesses the role of the renin-angiotensin system (RAS) in the renal alterations of the Lyon hypertensive (LH) rat by studying the renal function of LH rats and their normotensive controls at different pressure levels. Chronic blockade of the RAS; Increases in preglomerular vasoconstriction and a blunted pressure-natriuresis curve.

Studies the effects of physiological alterations in endogenous angiotensin II (ANG II) activity on basal renal sympathetic nerve activity and its arterial baroreflex regulation. Impact of intravenous losartan on arterial pressure; Shifts along the arterial pressure axis in the direction of the lateralization in arterial pressure.

Clarifies the role of endogenous angiotensin II (ANG II) on baroreflex control of heart rate both in normal, conscious rabbits and conscious rabbits with pacing-induced heart failure. Sympathetic nerve activity; Arterial pressure; Suggestion of a role for ANG II in regulating cardiac sympathetic outflow in heart failure.

Examines the role of the renin-angiotensin system in mediating the effects of posture on renal function. Neurohumoral activation associated with orthostatic stress on renal hemodynamics and sodium excretion; Renal blood flow; Contribution of angiotensin II to the effects of passive standing on renal hemodynamics and urinary sodium excretion.

Examines the mechanisms mediating hypertension in conscious rats during acute and chronic infusion of angiotensin II (ANG II) at pressor doses. Inverse relationship of trimethaphan-induced blood pressure to the acute dose of ANG II; Rapid transition from direct smooth muscle to indirect neural action; Ganglion blockade.

Determines the subcellular mechanisms involved in angiotensin II- (ANG II) and arginine vasopressin- (AVP) induced increases in intracellular free calcium in area postrema neurons. Indication that ANG II-induced increases in intracellular free calcium are independent of extracellular calcium concentrations; Pertussis toxin-sensitive G protein.

Focuses on the effect of plasma angiotensin on the blood pressure. Pathophysiological mediators controlling the secretion of hepatic angiotensinogen; Influence of change in angiotensinogen on the formation rate of angiotensin; Effect of angiotensinogen on the blood pressure.

Discusses the contribution of brain angiotensin III to ingestive behaviors in baboons. Aminopeptidase inhibitors found in baboons; Role of angiotensins in blood circulation of baboons.