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Studies the role of protein kinase C-alpha in the angiotensin (ANG) II-mediated inhibition of neuronal delayed rectifier potassium current. Role of phospholipase C in ANG II-mediated inhibition of neuronal delayed rectifier potassium current; Protein kinase C antisense knockdown of calcium-dependent protein kinase C isoenzymes.

Tests the hypothesis that desensitization of angiotensin (ANG) II tonic contractile response of the guinea pig ileum is related to membrane repolarization determined by calcium-activated potassium channel opening. Indirect effects of ANG II and acetylcholine on maxi-potassium channel activity; Kinetic parameters of the maxi-potassium channel.

Investigates whether angiotensin regulates the selectivity of the sodium-potassium pump for intracellular sodium. Pump current in left ventricular and right ventricular myocytes; Effect of captopril treatment on the pump's apparent affinity for extracellular potassium; Ability of potassium to act as an inhibitor of sodium activation of the pump.

Presents a study which examined the regulation of angiotensin II-induced Janus kinase-2 (JAK2) tyrosine phosphorylation. Methodology; Tyrosine phosphatase activity assay; Results.

Examines the effects of angiotensin II (ANG II) on sodium cotranmsport system. Concentration-dependent effects of ANG II; Mediation of the arachidonic acid pathway of the ANG II inhibitory effect; Role of protein kinase C in the stimulatory effect of ANG II.

Examines the activation of calcium-activated potassium channel by angiotensin II in myocytes of the guinea pig ileum. General properties of the channel; Indirect activation of maxi-potassium channel by angiotensin II; Voltage and calcium-dependence of maxi-potassium channel activation by angiotensin II.

Examines the differential translocation of protein kinase C isozymes by phorbol esters, epidermal growth factor (EGF), and angiotensin II (ANG II) in rat liver WB cells. Distribution of protein kinase C (PKC)-alpha in WB cells; Role of different PKC isoforms in signal transduction pathways.

Examines the influence of angiotensin II (ANG II) receptors on basic fibroblast growth factor (bFGF)-induced proliferation of bovine adrenocortical cells (BAC). Expression of ANG II receptors by BAC; Inhibition of bFGF-stimulated [3H]thymidine incorporation by ANG II; Influence of prostaglandins on bFGF-stimulated [3H]thymidine incorporation.

Tests the possibility that epidermal growth factor (EGF) regulates vascular angiotensin II (ANG II) action and receptor expression and signaling. Effects of EGF on vascular smooth muscle cells growth and integrity; Regulation of ANG II receptor density by EGF; Mechanisms of EGF-mediated reduction in ANG II Receptor density; Influence of EGF on ANG II formation.

Examines the modulatory effects of an angiotensin II (ANG II) type 1a (AT1a) receptor peptide on calcium and potassium currents. Effects of ANG II receptor synthetic peptides and ANG II on neuronal potassium and calcium currents; Influence of AT1a in the third cytoplasmic loop of the AT1 receptor on intracellular mechanisms of potassium and calcium currents.

Investigates the effect of angiotensin ligand CGP-42112 on human monocytes. Characterization of the binding of 125I-CGP-42112 to human monocytes; Effect of CGP-42112 on cell adhesion; Influence of CGP-42112 on cytokine release; Biochemical effects of CGP-42112 in human macrophages.

Elucidates on how angiotensin II (ANG II) activates the beta 1 isoform of phospholipase C (PLC) in vascular smooth muscle cells (VSMC). ANG II as growth factor in VSMC; ANG II as vasoconstrictor in VSMC; Role of PLC-beta 1 in ANG II-regulated signaling; ANG II as an important hormone for the control of rapid contraction and sustained VSMC processes.

Tests whether angiotensin II stimulates T-type Ca2+ channel currents via activation of a G protein. Cell isolation; Preparation of recombinant G protein subunits; Modulation of T-type Ca2+ channel current by ANG Ii; Lack of involvement of CaMKII; Transduction via a G protein.

Studies the intracellular mechanisms of angiotensin II type receptor modulation of neuronal K+ and Ca2+ currents. Experimental groups and data analysis; Hypothetical scheme for modulation of the decrease and increase of neuronal IK and ICa after AT1 receptor activation.

In this article, the author intracrine control mechanism by renin-angiotensin system (RAS) in hypothalamic neurons. Topics discussed include renin-angiotensin signaling, voltage imaging to examine the functionality of intracellular angiotensin type 1 (AT1) receptors and proposed mechanism of activation of AT1 receptor in endolysosomes.