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Studies the role of protein kinase C-alpha in the angiotensin (ANG) II-mediated inhibition of neuronal delayed rectifier potassium current. Role of phospholipase C in ANG II-mediated inhibition of neuronal delayed rectifier potassium current; Protein kinase C antisense knockdown of calcium-dependent protein kinase C isoenzymes.

Examines the activation of calcium-activated potassium channel by angiotensin II in myocytes of the guinea pig ileum. General properties of the channel; Indirect activation of maxi-potassium channel by angiotensin II; Voltage and calcium-dependence of maxi-potassium channel activation by angiotensin II.

Examines the modulatory effects of an angiotensin II (ANG II) type 1a (AT1a) receptor peptide on calcium and potassium currents. Effects of ANG II receptor synthetic peptides and ANG II on neuronal potassium and calcium currents; Influence of AT1a in the third cytoplasmic loop of the AT1 receptor on intracellular mechanisms of potassium and calcium currents.