1. Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study
- Author
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Amit Ovental, Yael Koren, Ronit Lubetzky, Varda Deutsch, Dror Mandel, Amir Hadanny, and Hadar Moran-Lev
- Subjects
medicine.medical_specialty ,Neonatal intensive care unit ,Anemia ,Inflammation ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Hepcidin ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Vitamin D and neurology ,030304 developmental biology ,0303 health sciences ,biology ,business.industry ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Ferritin ,Pediatrics, Perinatology and Child Health ,Etiology ,biology.protein ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVE The etiology of anemia in premature neonates is multifactorial and may involve anemia of inflammation mediated by hepcidin. Hepcidin expression is suppressed by vitamin D. We aimed to investigate the interrelationship between hepcidin, anemia, and vitamin D status in preterm infants. STUDY DESIGN Preterm infants aged 1 to 5 weeks were prospectively recruited at the neonatal intensive care unit of the Dana Dwek Children Hospital. Blood counts and serum levels of hepcidin, ferritin, iron, 25-hydroxyvitamin D [25(OH)D] and C-reactive protein (CRP) were measured and compared between anemic and nonanemic preterm infants. RESULTS Forty-seven preterm infants (mean ± standard deviation gestational age at birth 32.8 ± 1.1 weeks, 66% males) were recruited. In total, 36% of the preterm infants were vitamin D deficient [25(OH)D
- Published
- 2021