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Start Over Descriptor "Speech Intelligibility drug effects" Journal american journal of otology

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1. Noradrenergic cerebral stimulation of sensorineural impaired subjects: yohimbine effects on speech intelligibility and the auditory brain response.

Author

Hughes EC, Gott PS, Weinstein RC, and Binggeli R

Subjects
Aged, Audiometry, Evoked Response, Brain metabolism, Brain physiopathology, Double-Blind Method, Female, Hearing Loss, Sensorineural physiopathology, Humans, Male, Middle Aged, Noise, Norepinephrine metabolism, Speech Reception Threshold Test, Brain drug effects, Hearing Loss, Sensorineural drug therapy, Norepinephrine physiology, Speech Intelligibility drug effects, Yohimbine therapeutic use
Abstract

Norepinephrine has been shown to improve signal-to-noise ratios of sensory systems, including that of the auditory system. Yohimbine has been observed to cause a selective increase of cerebral norepinephrine. It was administered in one dose to sensorineurally impaired subjects with the object of improving their speech hearing in noise. Speech intelligibility was measured by the adaptive procedure. Mild, significant improvement was noted in one of the hearing components, "attenuation," and an adverse effect was shown on "distortion," owing to noise. Auditory brainstem response was improved significantly. The objective of temporarily improving intelligibility in noise was not attained.

Published
1988

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