1. Expression of nonclassical molecule human leukocyte antigen-G in oral lesions.
- Author
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Fregonezi PA, Silva TG, Simões RT, Moreau P, Carosella ED, Kläy CP, Gonçalves MA, Soares EG, Souto F, Donadi EA, and Soares CP
- Subjects
- Biomarkers, Tumor biosynthesis, Biomarkers, Tumor immunology, Biopsy, Cross-Sectional Studies, Follow-Up Studies, HLA-G Antigens immunology, Humans, Immunohistochemistry, Mouth Mucosa metabolism, Mouth Mucosa pathology, Mouth Neoplasms immunology, Mouth Neoplasms pathology, Retrospective Studies, HLA-G Antigens biosynthesis, Immunity, Cellular, Mouth Neoplasms metabolism
- Abstract
Introduction: Human leukocyte antigen (HLA)-G is a nonclassic class I molecule that acts as a modulator of immune responses, and the expression of these molecules in virus-infected cells has been associated with subversion of the immune response., Objective: In this study, we performed a cross-sectional study, systematically comparing the expression of the HLA-G in benign, premalignant, and malignant oral lesions and correlating it with the presence of high-risk and low-risk human papillomavirus (HPV) types. SPECIMENS AND METHODS: Oral biopsies were collected from 51 patients and analyzed by immunohistochemistry using anti-HLA-G antibody. Human papillomavirus detection and typing from oral biopsies were obtained by polymerase chain reaction using GP5+/GP6+ and specific primers., Results: The 51 biopsies were stratified into 3 groups according to lesion grade: oral benign lesions (oral hyperplasia and papilloma, n = 16), oral premalignant lesions (oral leukoplakia with dysplasia and lichen planus, n = 17), and malignant lesions (oral squamous cell carcinoma, n = 18). Human leukocyte antigen-G overexpression was mainly observed in benign and premalignant oral lesions but was not related to HPV infection (P > .05). On the other hand, HPV DNA was detected in 24 (47%) oral lesions, mainly in benign and premalignant lesions, with the most frequent type detected being high-risk HPV type., Conclusion: The HLA-G molecule was expressed in a significant number of benign oral lesions and was not correlated with HPV infection or oral cancer., (Crown Copyright © 2012. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
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