1. Risk Factors for Secondary Glaucoma in Herpetic Anterior Uveitis
- Author
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Lisette Hoeksema, Leonoor I. Los, Nomdo M. Jansonius, Perceptual and Cognitive Neuroscience (PCN), and Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
- Subjects
Male ,Intraocular pressure ,Herpesvirus 3, Human ,Viral/genetics ,Viral/virology ,Herpetic/virology ,genetic structures ,Eye Infections ,Glaucoma ,Eye Infections, Viral ,Anterior/virology ,Antibodies, Viral ,Viral/blood ,Polymerase Chain Reaction ,Herpes Zoster Ophthalmicus/virology ,Cohort Studies ,0302 clinical medicine ,Antibodies, Viral/blood ,Risk Factors ,80 and over ,Simplexvirus ,Child ,Aged, 80 and over ,education.field_of_study ,Human/genetics ,Incidence ,Middle Aged ,Uveitis, Anterior ,030220 oncology & carcinogenesis ,Child, Preschool ,Uveitis, Anterior/virology ,Female ,Uveitis ,Adult ,medicine.medical_specialty ,Open angle glaucoma ,Adolescent ,Population ,Antibodies ,Tonometry ,03 medical and health sciences ,Tonometry, Ocular ,Ophthalmology ,Ocular ,Glaucoma/epidemiology ,medicine ,Simplexvirus/genetics ,Humans ,Risk factor ,education ,Preschool ,Intraocular Pressure ,Aged ,Retrospective Studies ,Keratitis ,business.industry ,Herpesvirus 3 ,Retrospective cohort study ,DNA ,Eye infection ,medicine.disease ,DNA, Viral/genetics ,eye diseases ,Eye Infections, Viral/virology ,Herpesvirus 3, Human/genetics ,Keratitis, Herpetic/virology ,DNA, Viral ,030221 ophthalmology & optometry ,Herpes Zoster Ophthalmicus ,Keratitis, Herpetic ,sense organs ,business - Abstract
PURPOSE: To determine the incidence of elevated intraocular pressure (TOP) and secondary glaucoma in herpetic anterior uveitis (AU), owing to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of glaucoma.DESIGN: Retrospective observational cohort study.METHODS: Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included. Main outcome measures were the incidence of elevated KW and glaucoma and risk factors for the development of glaucoma.RESULTS: Seventy-three herpetic AU patients were included. Ocular complications most commonly seen during follow-up for uveitis were elevated IOP (75%), keratitis (59%), dry eyes (34%), posterior synechiae (34%), cataract (32%), and glaucoma (15%). Glaucoma patients, in comparison to non-glaucoma patients, had a higher number of IOP peaks during their follow-up for uveitis (P CONCLUSIONS: Using the SUN criteria, our study confirmed that elevated IOP and secondary glaucoma are major complications in herpetic AU. If an elevated IOP occurred, it was usually already present at the start of a uveitis episode. A risk factor for the development of glaucoma was the number of endured IOP peaks. Future studies are needed to evaluate whether early and prolonged use of antiviral and IOP-lowering medication may prevent glaucoma.
- Published
- 2017